Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents

被引：40

作者：

Tiwari, Shailendra ^{[1
]}

Pathak, Poonam ^{[1
]}

Sagar, Ram ^{[2
]}

机构：

[1] Univ Allahabad, Dept Chem, Allahabad 211002, UP, India

[2] Shiv Nadar Univ, Dept Chem, NH-91 Dadri, Gb Nagar 201314, UP, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 10期

关键词：

2,3-Dihydrooxazole-spirooxindole; Isatin; Spirooxindole; Hydrazide; Schiff base; Antimicrobial antibacterial activity; Antimicrobial antifungal activity; SPIROOXINDOLES; DESIGN; DERIVATIVES;

D O I：

10.1016/j.bmcl.2016.03.093

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two series of new 2,3-dihydrooxazole-spirooxindole derivatives were efficiently synthesized starting from N'-(2-oxoindolin-3-ylidene) benzohydrazide/N'-(2-oxoindolin-3-ylidene)-2-phenoxyacetohydrazide using designed synthetic route. Newly synthesized 2,3-dihydrooxazole-spirooxindole derivatives were screened for their antibacterial and antifungal activity against different pathogenic strain of bacteria and fungi. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined for the test compounds as well as for reference standards. Compounds 4e, 4g, 7g have shown good antibacterial activity whereas compounds 4f, 7b, 7d have displayed better antifungal activity. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：2513 / 2516

页数：4

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