Simple and practical procedure for Knoevenagel condensation under solvent-free conditions

被引：39

作者：

Muralidhar, L. ^{[1
]}

Girija, C. R. ^{[1
]}

机构：

[1] SSMRV Coll, Chem Res Ctr, Bangalore 560041, Karnataka, India

来源：

JOURNAL OF SAUDI CHEMICAL SOCIETY | 2014年 / 18卷 / 05期

关键词：

Aldehydes; Malononitrile; Knoevenagel condensation; Solvent-free conditions; CATALYST; CHLORIDE; ACID;

D O I：

10.1016/j.jscs.2011.10.024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The Knoevenagel condensation reaction between araldehyde and active methylene using gallium chloride catalyst under solvent-free conditions has been described. The reaction takes place at room temperature by grind stone method and offers good purity of product in high yield. Workup is very simple and the products do not need further purification. The reaction conditions are very mild and this protocol is applicable to various aldehydes such as araldehydes and heteroaromatic aldehydes as well as active methylene compounds, namely, malononitrile or ethyl cyanoacetate. [GRAPHICS] (C) 2011 Production and hosting by Elsevier B.V. on behalf of King Saud University.

引用

页码：541 / 544

页数：4

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