Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum

被引：149

作者：

Etxeberria, Ainhoa ^{[1
]}

Mangin, Jean-Marie ^{[1
]}

Aguirre, Adan ^{[1
]}

Gallo, Vittorio ^{[1
]}

机构：

[1] Childrens Natl Med Ctr, Ctr Neurosci Res, Washington, DC 20010 USA

来源：

NATURE NEUROSCIENCE | 2010年 / 13卷 / 03期

基金：

美国国家卫生研究院;

关键词：

OLIGODENDROCYTE DEVELOPMENT; SUBVENTRICULAR ZONE; WHITE-MATTER; GLUTAMATE; AXONS; RELEASE;

D O I：

10.1038/nn.2500

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.

引用

页码：287 / 289

页数：3

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