Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

被引：804

作者：

Liu, Hong-Wen ^{[1
]}

Chen, Lanlan ^{[1
,2
]}

Xu, Chengyan ^{[1
]}

Li, Zhe ^{[1
]}

Zhang, Haiyang ^{[1
]}

Zhang, Xiao-Bing ^{[1
]}

Tan, Weihong ^{[1
]}

机构：

[1] Hunan Univ, Mol Sci & Biomedicine Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Collaborat Innovat Ctr Chem, Changsha 410082, Hunan, Peoples R China

[2] Linyi Univ, Shandong Prov Key Lab Detect Technol Tumor Marker, Coll Chem & Chem Engn, Linyi 276005, Peoples R China

来源：

CHEMICAL SOCIETY REVIEWS | 2018年 / 47卷 / 18期

基金：

中国国家自然科学基金;

关键词：

AGGREGATION-INDUCED EMISSION; FIBROBLAST-ACTIVATION PROTEIN; GAMMA-GLUTAMYL-TRANSPEPTIDASE; LIGHT-UP PROBE; BETA-GALACTOSIDASE ACTIVITY; METHIONINE SULFOXIDE REDUCTASES; ALKALINE-PHOSPHATASE ACTIVITY; CELL-PENETRATING PEPTIDES; INDUCED LIVER-INJURY; TURN-ON PROBE;

D O I：

10.1039/c7cs00862g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Abnormal enzymatic activities are directly related to the development of cancers. Identifying the location and expression levels of these enzymes in live cancer cells have considerable importance in early-stage cancer diagnoses and monitoring the efficacy of therapies. Small-molecule fluorescent probes have become a powerful tool for the detection and imaging of enzymatic activities in biological systems by virtue of their higher sensitivity, nondestructive fast analysis, and real-time detection abilities. Moreover, due to their structural tailorability, numerous small-molecule enzymatic fluorescent probes have been developed to meet various demands involving real-time tracking and visualizing different enzymes in live cancer cells or in vivo. In this review, we provide an overview of recent advances in small-molecule enzymatic fluorescent probes mainly during the past decade, including the design strategies and applications for various enzymes in live cancer cells. We also highlight the challenges and opportunities in this rapidly developing field of small-molecule fluorescent probes for interventional surgical imaging, as well as cancer diagnosis and therapy.

引用

页码：7140 / 7180

页数：41

共 364 条

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