Functionalized 4-Aminoquinolines by Rearrangement of Pyrazole N-Heterocyclic Carbenes

被引：67

作者：

Schmidt, Andreas ^{[1
]}

Muenster, Niels ^{[1
]}

Dreger, Andrij ^{[1
]}

机构：

[1] Tech Univ Clausthal, Inst Organ Chem, D-38678 Clausthal Zellerfeld, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 15期

关键词：

carbenes; heterocycles; rearrangements; synthetic methods; zwitterions; STABLE 5-MEMBERED-RING ALLENES; MESOMERIC BETAINES; PALLADIUM(II) PYRAZOLIN-4-YLIDENES; CATALYTIC APPLICATION; COMPLEXES; DECARBOXYLATION; ALKALOIDS; CHEMISTRY; CARBOXYLATES; CONJUGATION;

D O I：

10.1002/anie.200905436

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) Thermal decarboxylation of 1-phenyl pyrazolium-3- carboxylates from the mesomeric betaine class of substances leads to pyrazole-N-heterocyclic carbenes, which immediately rearrange to multiply substituted 4-aminoquinolines (see scheme). These species are of interest for the synthesis of heterocycles and pharmacologically active compounds. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2790 / 2793

页数：4

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