New Phenanthrenes and Stilbenes from Dendrobium loddigesii

被引：50

作者：

Ito, Masanobu ^{[1
]}

Matsuzaki, Keiichi ^{[1
]}

Wang, Jue ^{[1
,2
]}

Daikonya, Akihiro ^{[1
]}

Wang, Nai-Li ^{[2
]}

Yao, Xin-Sheng ^{[3
]}

Kitanaka, Susumu ^{[1
]}

机构：

[1] Nihon Univ, Sch Pharm, Res Unit Pharmacognosy, Chiba 2748555, Japan

[2] Shenyang Pharmaceut Univ, Dept Nat Prod Chem, Shenyang 110015, Peoples R China

[3] Jinan Univ, Inst Tradit Chinese Med & Nat Prod, Guangzhou 510632, Guangdong, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 05期

关键词：

Dendrobium loddigesii; phenanthrene; stilbene; loddigesiinol; nitric oxide; 2,2-diphenyl-1-picrylhydrazyl radical scavenging; BIBENZYL DERIVATIVES; 9,10-DIHYDROPHENANTHRENE; CANDIDUM; SPECTRA; NOBILE;

D O I：

10.1248/cpb.58.628

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

New phenanthrenes, loddigesiinols A (1) and B (7), and stilbenes, loddigesiinols C (8) and D (9), were isolated from 80% ethanol extract of Dendrobium loddigesii ROLFE (Orcharedceae) along with known compounds, including five phenanthrenes, three stilbenes, two lignans, and three sterols. Their structures were determined by spectroscopic studies. These compounds were evaluated for their inhibitory activities against nitric oxide (NO) production and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging. Phenanthrenes (1-3, 7) and dihydrophenanthrenes (4-6) showed significant inhibitory activity against NO production. In particular, 2 showed stronger inhibitory activity against NO production than 5 and 6. This suggested that this phenanthrene is a stronger inhibitor of NO production than dihydrophenanthrene. The new phenanthrenes, loddigesiinols A (1) and B (7), significantly inhibited NO production with IC50 values of 2.6 and 10.9 mu M, respectively. One new dihydrostilbene, loddigesiinol D (9), showed weak inhibitory activity against NO production with an IC50 value of 69.7 mu M, but the other new dihydrostilbene, loddigesiinol C (8), did not show this activity at 100 mu M.

引用

页码：628 / 633

页数：6

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