A facile synthesis of aryl spirodioxines based on a 3H,3′H-2,2′-Spiro-bi(benzo[b][1,4]dioxine) skeleton

被引：15

作者：

Brimble, Margaret A. ^{[1
]}

Liu, Yen-Cheng ^{[1
]}

Trzoss, Michael ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland 1142, New Zealand

来源：

SYNTHESIS-STUTTGART | 2007年 / 9卷 / 09期

关键词：

D O I：

10.1055/s-2007-966016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a series of 6,6-bisbenzannulated spiroketals containing a 3H,3'H-2,2'-spirobi(benzo[b][1,4]dioxine) ring system is reported. The key step involves addition of a monobenzyl-protected catechol to the epoxide unit of a glycidol bearing a benzyl-protected catechol. The resultant alcohol adduct is oxidized to a ketone that then undergoes hydrogenation and acid-catalyzed cyclization to produce the desired spirodioxines.

引用

页码：1392 / 1402

页数：11

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