Biocatalytic Oxidation Reactions: A Chemist's Perspective

被引：352

作者：

Dong, JiaJia ^{[1
]}

Fernandez-Fueyo, Elena ^{[1
]}

Hollmann, Frank ^{[1
]}

Paul, Caroline E. ^{[1
]}

Pesic, Milja ^{[1
]}

Schmidt, Sandy ^{[1
]}

Wang, Yonghua ^{[2
]}

Younes, Sabry ^{[1
]}

Zhang, Wuyuan ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, van der Maasweg 9, NL-2629 HZ Delft, Netherlands

[2] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2018年 / 57卷 / 30期

基金：

欧盟地平线“2020”;

关键词：

Baeyer-Villiger oxidation; biocatalysis; halogenation; oxidation; oxyfunctionalisation; BAEYER-VILLIGER MONOOXYGENASES; C-H AMINATION; ENZYME CASCADE SYNTHESIS; CATALYZED OXYFUNCTIONALIZATION REACTIONS; EPSILON-CAPROLACTONE SYNTHESIS; CHEMOENZYMATIC TOTAL-SYNTHESIS; BROAD SUBSTRATE-SPECIFICITY; LIVER ALCOHOL-DEHYDROGENASE; GUIDED DIRECTED EVOLUTION; NITROGEN-ATOM TRANSFER;

D O I：

10.1002/anie.201800343

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidation chemistry using enzymes is approaching maturity and practical applicability in organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists to perform highly selective and efficient transformations ranging from simple alcohol oxidations to stereoselective halogenations of non-activated C-H bonds. For many of these reactions, no "classical" chemical counterpart is known. Hence oxidoreductases open up shorter synthesis routes based on a more direct access to the target products. The generally very mild reaction conditions may also reduce the environmental impact of biocatalytic reactions compared to classical counterparts. In this Review, we critically summarise the most important recent developments in the field of biocatalytic oxidation chemistry and identify the most pressing bottlenecks as well as promising solutions.

引用

页码：9238 / 9261

页数：24

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