Cryoglobulinemic vasculitis in chronic hepatitis C: Genetic aspects

被引：0
作者：
Artemova, M. G. [1 ]
Abdurakhmanov, D. T. [2 ]
机构：
[1] Moscow MV Lomonosov State Univ, Moscow, Russia
[2] IM Sechenov First Moscow State Med Univ, Minist Hlth Russia, Moscow, Russia
来源：
TERAPEVTICHESKII ARKHIV | 2017年 / 89卷 / 04期
关键词：
hepatitis C virus; cryoglobulinemia; cryoglobulinemic vasculitis; genetic aspects; ESSENTIAL MIXED CRYOGLOBULINEMIA; GENOME-WIDE ASSOCIATION; ACTIVATING FACTOR BAFF; CLASS-II ALLELES; VIRUS-INFECTION; FIBRONECTIN GENE; LYMPHOPROLIFERATIVE DISORDERS; HYPERVARIABLE REGION-1; PROMOTER POLYMORPHISM; ANTIGEN;
D O I：
10.17116/terarkh2017894110-114
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cryoglobulinemia (CG) is detected in more than 50% of patients with chronic hepatitis C (CHC); however, only 15-25% of them develop cryoglobulinemic vasculitis (CV) that is a systemic vasculitis due to the formation of immune deposits, which affects small (less than medium-sized) vessels and which is frequently fatal for the patient. The causes of CG only in some patients with CHC and the pathogenesis of CV remain unstudied; however, the accumulated data allow one to identify the special contribution of the patient's genetic factors to the development of the disease. The paper considers the genetic aspects of the development of CG and CV in CHC.
引用
收藏
页码：110 / 114
页数：5
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