Disorganization of anatomical connectivity in obsessive compulsive disorder: A multi-parameter diffusion tensor imaging study in a subpopulation of patients

被引：91

作者：

Garibotto, V. ^{[1
,2
,3
]}

Scifo, P. ^{[2
,3
,4
]}

Gorini, A. ^{[1
]}

Alonso, Clarke R. ^{[2
,3
]}

Brambati, S. ^{[1
]}

Bellodi, L. ^{[1
,5
]}

Perani, D. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Vita Salute San Raffaele, I-20132 Milan, Italy

[2] Ist Sci San Raffaele, Nucl Med Unit, I-20132 Milan, Italy

[3] Ist Sci San Raffaele, Div Neurosci, I-20132 Milan, Italy

[4] Ist Sci San Raffaele, CERMAC, I-20132 Milan, Italy

[5] Ist Sci San Raffaele, Dept Clin Neurosci, I-20132 Milan, Italy

来源：

NEUROBIOLOGY OF DISEASE | 2010年 / 37卷 / 02期

关键词：

Obsessive compulsive disorder (OCD); White matter; Connectivity; Diffusion tensor imaging (DTI); Fiber tracts; Visuospatial functions; WHITE-MATTER ABNORMALITIES; DECISION-MAKING; NEURODEVELOPMENTAL MODEL; SYMPTOM DIMENSIONS; METABOLIC-CHANGES; BRAIN; DEFICITS; SCHIZOPHRENIA; TRACTOGRAPHY; ARCHITECTURE;

D O I：

10.1016/j.nbd.2009.11.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

obsessive-compulsive disorder (OCD) is thought to involve large-scale brain systems but the anatomical connectivity via association fibers has not been specifically investigated yet. We evaluated organization and directionality of the major fiber bundles in a subpopulation of OCD, including washers and checkers who presented decision making deficits, by measuring MRI parameters related to water self-diffusion (Fractional Anisotropy, FA) and fiber directionality (Principal Diffusion Direction, PDD) in 15 OCD and 16 control subjects. OCD patients showed significantly lower FA and altered PDD along the corpus callosum, cingulum, superior longitudinal fasciculus, and inferior fronto-occipital fasciculus bilaterally. The track-based analysis of the inferior fronto-occipital fasciculus confirmed a significant bilateral FA reduction. Lower FA values in the inferior fronto-occipital fasciculus, superior longitudinal fasciculus and corpus callosum correlated with symptom severity and neuropsychological performance. This multi-parameter MRI study revealed specific white matter abnormalities in OCD suggesting tract disorganization as main feature, reflected by local changes in fiber directionality. This altered anatomical connectivity might play a specific role in OCD pathophysiology. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：468 / 476

页数：9

共 77 条

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