The developmental origin of brain tumours: a cellular and molecular framework

被引：90
作者：
Azzarelli, Roberta [1 ,2 ,4 ]
Simons, Benjamin D. [2 ,3 ,4 ]
Philpott, Anna [1 ,2 ]
机构：
[1] Univ Cambridge, Dept Oncol, Hutchison MRC Res Ctr, Cambridge Biomed Campus, Cambridge CB2 0XZ, England
[2] Univ Cambridge, Wellcome Trust Ctr Stem Cell Res, Tennis Court Rd, Cambridge CB2 1QR, England
[3] Univ Cambridge, Wellcome Trust, Canc Res UK Gurdon Inst, Tennis Court Rd, Cambridge CB2 1QN, England
[4] Univ Cambridge, Cavendish Lab, Dept Phys, JJ Thomson Ave, Cambridge CB3 0HE, England
来源：
DEVELOPMENT | 2018年 / 145卷 / 10期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
CANCER STEM-CELLS; CENTRAL-NERVOUS-SYSTEM; ACUTE PROMYELOCYTIC LEUKEMIA; LINEAGE-SURVIVAL ONCOGENES; PEDIATRIC HIGH-GRADE; NEURONAL DIFFERENTIATION; TRANSCRIPTIONAL DEPENDENCIES; BROMODOMAIN PROTEINS; PERIVASCULAR NICHE; INITIATING CELLS;
D O I：
10.1242/dev.162693
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The development of the nervous system relies on the coordinated regulation of stem cell self-renewal and differentiation. The discovery that brain tumours contain a subpopulation of cells with stem/progenitor characteristics that are capable of sustaining tumour growth has emphasized the importance of understanding the cellular dynamics and the molecular pathways regulating neural stem cell behaviour. By focusing on recent work on glioma and medulloblastoma, we review how lineage tracing contributed to dissecting the embryonic origin of brain tumours and how lineage-specific mechanisms that regulate stem cell behaviour in the embryo may be subverted in cancer to achieve uncontrolled proliferation and suppression of differentiation.
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页数：12
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