Antinociceptive C19-Diterpenoid Alkaloids from Aconitum episcopale

被引：5

作者：

Hu, Jiang ^{[1
]}

Li, Jiaxun ^{[2
]}

Li, Qiang ^{[1
]}

Mao, Xia ^{[1
]}

Peng, Tianfeng ^{[1
]}

Jin, Nianhua ^{[1
]}

Yin, Si ^{[1
]}

Shi, Xiaodong ^{[1
]}

Li, Yu ^{[3
]}

机构：

[1] Qujing Normal Univ, Coll Biol Resources & Food Engn, Qujing 655011, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 3, Tumor Hosp Yunnan Prov, Kunming 650118, Yunnan, Peoples R China

[3] Gen Hosp Northern Theater Command Chinese PLA, Dept Orthoped, Shenyang 110016, Liaoning, Peoples R China

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2021年 / 57卷 / 03期

关键词：

Aconitum episcopale; Ranunculaceae; C-19-diterpenoid alkaloids; antinociceptive activity; DITERPENOID ALKALOIDS;

D O I：

10.1007/s10600-021-03397-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A chemical investigation of the 80% ethanol extract of the roots of Aconitum episcopale led to the isolation of two undescribed C-19-diterpenoid alkaloids, designated as episcopines A and B. The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for antinociceptive potential. Episcopine A showed a 2-fold more potent antinociceptive effect (ID50 = 66.1 mu mol/kg) than the positive control drugs aspirin and acetaminophen.

引用

页码：503 / 506

页数：4

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