Potential activity of Traditional Chinese Medicine against Ulcerative colitis: A review

被引：166
作者：
Liu, Yang [1 ,2 ,4 ]
Li, Bao-Guo [1 ]
Su, Yu-Hua [3 ]
Zhao, Ruo-Xi [5 ]
Song, Peng [1 ,2 ,4 ]
Li, Hui [2 ,4 ]
Cui, Xin-Hai [1 ,2 ,4 ]
Gao, Hong-Mei [2 ,4 ]
Zhai, Run-Xiang [2 ,4 ]
Fu, Xian-Jun [2 ,4 ]
Ren, Xia [2 ,4 ]
机构：
[1] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Marine Tradit Chinese Med Res Ctr, Qingdao Acad, 4566 HeDong Rd, Qingdao 266114, Peoples R China
[3] Weifang Med Coll, Affiliated Hosp, Dept Immunol & Rheumatol, Weifang 261000, Peoples R China
[4] Shandong Engn & Technol Res Ctr Tradit Chinese Me, Jinan 250355, Peoples R China
[5] Shandong Univ Tradit Chinese Med, Jinan 250355, Peoples R China
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2022年 / 289卷
基金：
中国国家自然科学基金;
关键词：
Ulcerative colitis; Therapeutic drugs; Traditional Chinese medicine; Mechanism; INFLAMMATORY-BOWEL-DISEASE; NF-KAPPA-B; RATS; MICE; POLYSACCHARIDES; INVOLVEMENT; MEDIATORS; EXTRACT; BARRIER; DRUG;
D O I：
10.1016/j.jep.2022.115084
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ethnic pharmacological relevance: Plant materials are used as complementary and alternative therapies all over the world for the treatment of various diseases. Ulcerative colitis (UC), a chronic nonspecific inflammatory bowel disease listed as one of the modern refractory diseases by the World Health Organization, has a long course, is challenging to cure, and is prone to cause cancer. Recent years have witnessed a growing trend of applying traditional Chinese medicine (TCM) to UC.Aim of this review: This review presents an overview of the pathogenesis of UC and reports the therapeutic effect of TCM on UC (including TCM prescriptions, single TCM, and treatments using TCM ingredients) to provide a theoretical basis for the use of TCM in treating UC. Methods: We performed a collection and collation of relevant scientific articles from different scientific databases regarding TCM and its usefulness in treating UC. In this paper, the therapeutic effect of TCM is summarized and analyzed according to the existing experimental and clinical research.Results: There are positive signs that TCM primarily regulates inflammatory cytokines, intestinal flora, and the immune system, and also protects the intestinal mucosa. Hence, it can play a role in treating UC.Conclusion: TCM has a definite curative effect in the treatment of UC. It can alleviate and treat UC in a variety of ways. We should take syndrome differentiation and treatment differentiation as the basis. With the help of modern medicine, TCM's clinical curative effects can be enhanced for the treatment of UC.
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页数：14
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