TGF-β knockout and dominant-negative receptor transgenic mice

被引：48
作者：
Letterio, JJ
Böttinger, EP
机构：
[1] NCI, Chemoprevent Lab, NIH, Bethesda, MD 20892 USA
[2] Albert Einstein Coll Med, Dept Med, Bronx, NY 10467 USA
来源：
MINERAL AND ELECTROLYTE METABOLISM | 1998年 / 24卷 / 2-3期
关键词：
TGF-beta; mice; transgenic; knockout; inflammation; development; malignancy;
D O I：
10.1159/000057365
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Use of homologous recombination and transgenic technologies have provided mouse models to study the physiological roles of the three mammalian TGF-beta isoforms, and their regulation in the context of the intact animal. Mice harboring null mutations for TGF-beta isoforms demonstrate that each exerts discrete nonoverlapping functions during development. TGF-beta 1 null mice reveal a crucial role for this cytokine in modulation of the immune system, with evidence for altered development, activation and function of various immune cell populations. New approaches to tissue-and cell-restricted disruption of TGF-beta signaling pathways in transgenic mice carrying dominant-negative mutant TGF-beta receptors will be discussed.
引用
收藏
页码：161 / 167
页数：7
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