Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity

被引：7
作者：
Sun, Hai Ling [2 ]
Wang, Tian Tian [2 ]
Lv, Zhi Liang [2 ]
Feng, Ji Lu [2 ]
Geng, Dong Ping [2 ]
Li, Yong Mei [1 ]
Li, Ke [2 ]
机构：
[1] Second Mil Med Univ, Dept Oncol, Changhai Hosp, Shanghai 200433, Peoples R China
[2] Second Mil Med Univ, Dept Med Chem, Coll Pharm, Shanghai 200433, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Furan lignan; Selectively hydrolization; Circular dichroism spectra; Absolute configuration; Anticancer; QGY-7701; HeLa cell; CIRCULAR-DICHROISM; ANALOGS;
D O I：
10.1016/j.bmcl.2010.01.122
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A kind of racemic furan lignans were synthesized via a novel route, and two optical isomers were obtained through a selective hydrolization. The absolute configurations were determined by circular dichroism spectroscopy after separated through a preparative column. The different activities of isomers and the racemates were evaluated on QGY-7701 and HeLa cell lines, and compound 2c showed the best activity on QGY-7701 and HeLa cell lines with IC50 12 mu M and 13 mu M, respectively. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
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页码：1961 / 1964
页数：4
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