Evidence for the Gut Microbiota Short-Chain Fatty Acids as Key Pathophysiological Molecules Improving Diabetes

被引：266

作者：

Puddu, Alessandra ^{[1
]}

Sanguineti, Roberta ^{[1
]}

Montecucco, Fabrizio ^{[1
,2
,3
]}

Viviani, Giorgio Luciano ^{[1
]}

机构：

[1] Univ Genoa, IRCCS Azienda Osped Univ San Martino, Dept Internal Med, Clin Internal Med 1, I-16143 Genoa, Italy

[2] Univ Hosp Geneva, Dept Med Specialties, Fdn Med Res, Div Cardiol, CH-1211 Geneva, Switzerland

[3] Univ Hosp Geneva, Dept Genet & Lab Med, Div Lab Med, CH-1205 Geneva, Switzerland

来源：

MEDIATORS OF INFLAMMATION | 2014年 / 2014卷

基金：

瑞士国家科学基金会;

关键词：

GLUCAGON-LIKE PEPTIDE-1; PROTEIN-COUPLED RECEPTOR; SODIUM-BUTYRATE; ADIPOSE-TISSUE; INTESTINAL MICROBIOTA; INSULIN SENSITIVITY; PLASMA; INFLAMMATION; PROPIONATE; EXPRESSION;

D O I：

10.1155/2014/162021

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In type 2 diabetes, hyperglycemia, insulin resistance, increased inflammation, and oxidative stress were shown to be associated with the progressive deterioration of beta-cell function and mass. Short-chain fatty acids (SCFAs) are organic fatty acids produced in the distal gut by bacterial fermentation of macrofibrous material that might improve type 2 diabetes features. Their main beneficial activities were identified in the decrease of serum levels of glucose, insulin resistance as well as inflammation, and increase in protective Glucagon-like peptide-1 (GLP-1) secretion. In this review, we updated evidence on the effects of SCFAs potentially improving metabolic control in type 2 diabetes.

引用

页数：9

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