The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer-Understanding the Basis of a Rapidly Evolving Disease

被引：27

作者：

Lechner, M. ^{[1
,2
]}

Fenton, T. R. ^{[2
]}

机构：

[1] Univ Coll London Hosp, Head & Neck Ctr, London, England

[2] UCL, Inst Canc, London, England

来源：

ADVANCES IN GENETICS, VOL 93 | 2016年 / 93卷

关键词：

SQUAMOUS-CELL CARCINOMA; HUMAN-PAPILLOMAVIRUS TYPE-16; RISK HUMAN-PAPILLOMAVIRUS; NECK-CANCER; DNA METHYLATION; MUTATIONAL PROCESSES; GENE-EXPRESSION; E7; ONCOPROTEIN; E6; GLOBAL HYPOMETHYLATION;

D O I：

10.1016/bs.adgen.2015.12.001

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Human papillomavirus (HPV) has been shown to represent a major independent risk factor for head and neck squamous cell cancer, in particular for oropharyngeal carcinoma. This type of cancer is rapidly evolving in the Western world, with rising trends particularly in the young, and represents a distinct epidemiological, clinical, and molecular entity. It is the aim of this review to give a detailed description of genomic, epigenomic, transcriptomic, and posttranscriptional changes that underlie the phenotype of this deadly disease. The review will also link these changes and examine what is known about the interactions between the host genome and viral genome, and investigate changes specific for the viral genome. These data are then integrated into an updated model of HPV-induced head and neck carcinogenesis.

引用

页码：1 / 56

页数：56

共 200 条

[1] FGFR3 Translocations in Bladder Cancer: Differential Sensitivity to HSP90 Inhibition Based on Drug Metabolism [J].

Acquaviva, Jaime ;

He, Suqin ;

Zhang, Chaohua ;

Jimenez, John-Paul ;

Nagai, Masazumi ;

Sang, Jim ;

Sequeira, Manuel ;

Smith, Donald L. ;

Ogawa, Luisa Shin ;

Inoue, Takayo ;

Tatsuta, Noriaki ;

Knowles, Margaret A. ;

Bates, Richard C. ;

Proia, David A. .

MOLECULAR CANCER RESEARCH, 2014, 12 (07) :1042-1054

[2] Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 [J].

Agrawal, Nishant ;

Frederick, Mitchell J. ;

Pickering, Curtis R. ;

Bettegowda, Chetan ;

Chang, Kyle ;

Li, Ryan J. ;

Fakhry, Carole ;

Xie, Tong-Xin ;

Zhang, Jiexin ;

Wang, Jing ;

Zhang, Nianxiang ;

El-Naggar, Adel K. ;

Jasser, Samar A. ;

Weinstein, John N. ;

Trevino, Lisa ;

Drummond, Jennifer A. ;

Muzny, Donna M. ;

Wu, Yuanqing ;

Wood, Laura D. ;

Hruban, Ralph H. ;

Westra, William H. ;

Koch, Wayne M. ;

Califano, Joseph A. ;

Gibbs, Richard A. ;

Sidransky, David ;

Vogelstein, Bert ;

Velculescu, Victor E. ;

Papadopoulos, Nickolas ;

Wheeler, David A. ;

Kinzler, Kenneth W. ;

Myers, Jeffrey N. .

SCIENCE, 2011, 333 (6046) :1154-1157

[3] Signatures of mutational processes in human cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Aparicio, Samuel A. J. R. ;

Behjati, Sam ;

Biankin, Andrew V. ;

Bignell, Graham R. ;

Bolli, Niccolo ;

Borg, Ake ;

Borresen-Dale, Anne-Lise ;

Boyault, Sandrine ;

Burkhardt, Birgit ;

Butler, Adam P. ;

Caldas, Carlos ;

Davies, Helen R. ;

Desmedt, Christine ;

Eils, Roland ;

Eyfjord, Jorunn Erla ;

Foekens, John A. ;

Greaves, Mel ;

Hosoda, Fumie ;

Hutter, Barbara ;

Ilicic, Tomislav ;

Imbeaud, Sandrine ;

Imielinsk, Marcin ;

Jaeger, Natalie ;

Jones, David T. W. ;

Jones, David ;

Knappskog, Stian ;

Kool, Marcel ;

Lakhani, Sunil R. ;

Lopez-Otin, Carlos ;

Martin, Sancha ;

Munshi, Nikhil C. ;

Nakamura, Hiromi ;

Northcott, Paul A. ;

Pajic, Marina ;

Papaemmanuil, Elli ;

Paradiso, Angelo ;

Pearson, John V. ;

Puente, Xose S. ;

Raine, Keiran ;

Ramakrishna, Manasa ;

Richardson, Andrea L. ;

Richter, Julia ;

Rosenstiel, Philip ;

Schlesner, Matthias ;

Schumacher, Ton N. ;

Span, Paul N. ;

Teague, Jon W. .

NATURE, 2013, 500 (7463) :415-+

[4] Deciphering Signatures of Mutational Processes Operative in Human Cancer [J].

Alexandrov, Ludmil B. ;

Nik-Zainal, Serena ;

Wedge, David C. ;

Campbell, Peter J. ;

Stratton, Michael R. .

CELL REPORTS, 2013, 3 (01) :246-259

[5] Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer [J].

Ang, K. Kian ;

Harris, Jonathan ;

Wheeler, Richard ;

Weber, Randal ;

Rosenthal, David I. ;

Nguyen-Tan, Phuc Felix ;

Westra, William H. ;

Chung, Christine H. ;

Jordan, Richard C. ;

Lu, Charles ;

Kim, Harold ;

Axelrod, Rita ;

Silverman, C. Craig ;

Redmond, Kevin P. ;

Gillison, Maura L. .

NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (01) :24-35

[6] Human papillomavirus-16 DNA methylation patterns support a causal association of the virus with oral squamous cell carcinomas [J].

Balderas-Loaeza, Adriana ;

Anaya-Saavedra, Gabriela ;

Ramirez-Amador, Velia A. ;

Guido-Jimenez, Miriam C. ;

Kalantari, Mina ;

Calleja-Macias, Itzel E. ;

Bernard, Hans-Ulrich ;

Garcia-Carranca, Alejandro .

INTERNATIONAL JOURNAL OF CANCER, 2007, 120 (10) :2165-2169

[7] Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+ tumors when combined with an E6/E7 peptide vaccine [J].

Bartkowiak, Todd ;

Singh, Shailbala ;

Yang, Guojun ;

Galvan, Gloria ;

Haria, Dhwani ;

Ai, Midan ;

Allison, James P. ;

Sastry, K. Jagannadha ;

Curran, Michael A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (38) :E5290-E5299

[8] DNA methylation and gene silencing in cancer [J].

Baylin S.B. .

Nature Clinical Practice Oncology, 2005, 2 (Suppl 1) :S4-S11

[9] A decade of exploring the cancer epigenome - biological and translational implications [J].

Baylin, Stephen B. ;

Jones, Peter A. .

NATURE REVIEWS CANCER, 2011, 11 (10) :726-734

[10] Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies [J].

Bernardi, Rosa ;

Pandolfi, Pier Paolo .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2007, 8 (12) :1006-1016

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