Stereoselection in designed three-helix bundle metalloproteins

被引：28
作者：
Case, MA
Ghadiri, MR
Mutz, MW
McLendon, GL
机构：
[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA
[2] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
[4] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
CHIRALITY | 1998年 / 10卷 / 1-2期
关键词：
de novo design; self-assembly; metalloproteins; diastereoselection;
D O I：
10.1002/chir.7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems. (C) 1998 Wiley-Liss, Inc.
引用
收藏
页码：35 / 40
页数：6
相关论文
共 26 条
[1]   PROTEIN DESIGN - A HIERARCHICAL APPROACH [J].
BRYSON, JW ;
BETZ, SF ;
LU, HS ;
SUICH, DJ ;
ZHOU, HXX ;
ONEIL, KT ;
DEGRADO, WF .
SCIENCE, 1995, 270 (5238) :935-941
[2]   SELF-ASSEMBLING HEXAMERIC HELICAL BUNDLE FORMING PEPTIDES [J].
CHIN, TM ;
BERNDT, KD ;
YANG, NCC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (06) :2279-2280
[3]   HELICES, SUPRAMOLECULAR CHEMISTRY, AND METAL-DIRECTED SELF-ASSEMBLY [J].
CONSTABLE, EC .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (11) :1450-1451
[4]  
CONSTABLE EC, 1997, J CHEM SOC CHEM COMM, P489
[5]   DISTORTIONLESS ENHANCEMENT OF NMR SIGNALS BY POLARIZATION TRANSFER [J].
DODDRELL, DM ;
PEGG, DT ;
BENDALL, MR .
JOURNAL OF MAGNETIC RESONANCE, 1982, 48 (02) :323-327
[6]   CIS-TRANS PHOTOISOMERIZATION IN RU(BPY)2(OH2)22+ - CRYSTAL-STRUCTURE OF TRANS-[RU(BPY)2(OH2)(OH)](CLO4)2 [J].
DURHAM, B ;
WILSON, SR ;
HODGSON, DJ ;
MEYER, TJ .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (02) :600-607
[7]   A CONVERGENT APPROACH TO PROTEIN DESIGN - METAL ION-ASSISTED SPONTANEOUS SELF-ASSEMBLY OF A POLYPEPTIDE INTO A TRIPLE-HELIX BUNDLE PROTEIN [J].
GHADIRI, MR ;
SOARES, C ;
CHOI, C .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (03) :825-831
[8]   DE-NOVO DESIGN OF A NOVEL HETERODINUCLEAR 3-HELIX BUNDLE METALLOPROTEIN [J].
GHADIRI, MR ;
CASE, MA .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1993, 32 (11) :1594-1597
[9]   CRYSTAL-STRUCTURE OF AN ISOLEUCINE-ZIPPER TRIMER [J].
HARBURY, PB ;
KIM, PS ;
ALBER, T .
NATURE, 1994, 371 (6492) :80-83
[10]   A SWITCH BETWEEN 2-STRANDED, 3-STRANDED AND 4-STRANDED COILED COILS IN GCN4 LEUCINE-ZIPPER MUTANTS [J].
HARBURY, PB ;
ZHANG, T ;
KIM, PS ;
ALBER, T .
SCIENCE, 1993, 262 (5138) :1401-1407
123