Docosahexaenoic acid intake decreases proliferation, increases apoptosis and decreases the invasive potential of the human breast carcinoma cell line MDA-MB-231

被引:65
作者
Blanckaert, Vincent [1 ,2 ]
Ulmann, Lionel [1 ,2 ]
Mimouni, Virginie [1 ,2 ]
Antol, Johann [3 ]
Brancquart, Lucile [2 ]
Chenais, Benoit [2 ]
机构
[1] IUT Laval, MMS EA2160, Dept Genie Biol, F-53020 Laval 9, France
[2] Univ Maine, Mar Mol Sante EA2160, F-72085 Le Mans, France
[3] Univ Lille, INSERM, U908, F-59655 Villeneuve Dascq, France
关键词
apoptosis; breast cancer; carcinoma cell; docosahexaenoic acid; invasion; polyunsaturated fatty acid; FATTY-ACIDS; CANCER-CELLS; FISH-OIL; DIET; OMEGA-3-FATTY-ACIDS; MCF-7;
D O I
10.3892/ijo_00000549
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Breast cancer is the most common cancer in women in industrialized countries. Environmental factors, such as differences in diet are likely to have an important influence on cancer emergence. Among these factors, n-3 polyunsaturated-fatty acids, such as docosahexaenoic acid (DHA), are good candidates for preventing breast cancer. Here we investigate the effect of DHA on the human breast cancer cell line MDA-MB-231 and show that DHA incorporation i) has an anti-proliferative effect, ii) induces apoptosis via a transient increase in caspase-3 activity and the promotion of nuclear condensation, and iii) reduces the invasive potential of MDA-MB-231 cells. To conclude, DHA may have beneficial effects as a result of slowing the proliferation of tumor cells, and minimizing their metastatic potential.
引用
收藏
页码:737 / 742
页数:6
相关论文
共 50 条
[31]   Alisol A Suppresses Proliferation, Migration, and Invasion in Human Breast Cancer MDA-MB-231 Cells [J].
Lou, Chenghua ;
Xu, Xintong ;
Chen, Yan ;
Zhao, Huajun .
MOLECULES, 2019, 24 (20)
[32]   Fangchinoline inhibits migration and causes apoptosis of human breast cancer MDA-MB-231 cells [J].
Wang, Binggao ;
Xing, Zhibo ;
Wang, Fengmei ;
Yuan, Xinyan ;
Zhang, Yanhui .
ONCOLOGY LETTERS, 2017, 14 (05) :5307-5312
[33]   D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231 [J].
Cheng, Lin ;
Xia, Tian-Song ;
Shi, Liang ;
Xu, Lingyun ;
Chen, Weixian ;
Zhu, Yulan ;
Ding, Qiang .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 495 (01) :775-780
[34]   MELK as a potential target to control cell proliferation in triple-negative breast cancer MDA-MB-231 cells [J].
Li, Gang ;
Yang, Mei ;
Zuo, Li ;
Wang, Mei-Xing .
ONCOLOGY LETTERS, 2018, 15 (06) :9934-9940
[35]   Effects of FSTL1 on cell proliferation in breast cancer cell line MDA-MB-231 and its brain metastatic variant MDA-MB-231-BR [J].
An, Jiaqiang ;
Wang, Lulu ;
Zhao, Yuanli ;
Hao, Qiang ;
Zhang, Ying ;
Zhang, Jingyi ;
Yang, Chun ;
Liu, Li ;
Wang, Wenjuan ;
Fang, Dongliang ;
Lu, Tao ;
Gao, Yan .
ONCOLOGY REPORTS, 2017, 38 (05) :3001-3010
[36]   Pinolenic acid inhibits human breast cancer MDA-MB-231 cell metastasis in vitro [J].
Chen, Szu-Jung ;
Hsu, Chih-Ping ;
Li, Chi-Wei ;
Lu, Jui-Hua ;
Chuang, Lu-Te .
FOOD CHEMISTRY, 2011, 126 (04) :1708-1715
[37]   Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells [J].
Liu, Nan ;
Tian, Hao ;
Zhang, Guoduo ;
Sun, Na ;
Wang, Shumei .
MEDICAL ONCOLOGY, 2022, 39 (01)
[38]   Bevacizumab induces inflammation in MDA-MB-231 breast cancer cell line and in a mouse model [J].
El-Hajjar, Layal ;
Jalaleddine, Nour ;
Shaito, Abdullah ;
Zibara, Kazem ;
Kazan, Jalal M. ;
El-Saghir, Jamal ;
El-Sabban, Marwan .
CELLULAR SIGNALLING, 2019, 53 :400-412
[39]   Effect of combined treatment with lobaplatin and osthole on inducing apoptosis and inhibiting proliferation in human breast cancer MDA-MB-231 cells [J].
Nan Liu ;
Hao Tian ;
Guoduo Zhang ;
Na Sun ;
Shumei Wang .
Medical Oncology, 2022, 39
[40]   Ectophosphatase activity in the triple-negative breast cancer cell line MDA-MB-231 [J].
Lacerda-Abreu, Marco A. ;
Russo-Abrahao, Thais ;
Leite Tenorio Aguiar, Raissa ;
Monteiro, Robson de Queiroz ;
Rumjanek, Franklin D. ;
Meyer-Fernandes, Jose R. .
CELL BIOLOGY INTERNATIONAL, 2021, 45 (02) :411-421