Studies of Amyloid-Like Fibrillogenesis through β-Sheet-Mediated Self-Assembly of Short Synthetic Peptides

被引：5
|
作者：
Dutt, Anita [1 ]
Spencer, Elinor C. [2 ]
Howard, Judith A. K. [2 ]
Pramanik, Animesh [1 ]
机构：
[1] Univ Calcutta, Dept Chem, Kolkata 700009, W Bengal, India
[2] Univ Durham, Dept Chem, Durham DH1 3LE, England
来源：
CHEMISTRY & BIODIVERSITY | 2010年 / 7卷 / 02期
关键词：
OMEGA-AMINO ACIDS; SOLID-STATE; FIBRIL FORMATION; PARKINSONS-DISEASE; ALPHA-SYNUCLEIN; LEWY BODIES; HELIX; CONFORMATION; PROTEINS; PARALLEL;
D O I：
10.1002/cbdv.200900050
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Three structurally different types of small peptides, namely, i) Boc-Ile-Aib-Ile-OMe (Aib=alpha-aminoisobutyric acid), ii) Boc-Xx-m-aminobenzoic acid (Xx=beta-Ala and gamma-aminobutyric acid), and iii) Boc-Xx-m-nitroaniline, were found to exhibit beta-sheet-mediated fibrillogenesis in the solid state, revealed by FT-IR, single-crystal X-ray diffraction, and FE-SEM studies. Interestingly, the fibrils grown from peptides 2 and 3 were found to bind with the physiological dye Congo red, a characteristic feature of amyloid fibrils.
引用
收藏
页码：363 / 375
页数：13
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