Examining health-related quality of life patterns in women with breast cancer

被引:24
作者
Pinheiro, Laura C. [1 ]
Tan, Xianming [2 ]
Olshan, Andrew F. [3 ]
Wheeler, Stephanie B. [4 ]
Reeder-Hayes, Katherine E. [5 ]
Samuel, Cleo A. [4 ]
Reeve, Bryce B. [4 ]
机构
[1] Univ N Carolina, Dept Hlth Policy & Management, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Biostat, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
[3] Univ N Carolina, Dept Epidemiol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
[4] Univ N Carolina, Dept Hlth Policy & Management, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
[5] Univ N Carolina, Univ North Carolina Breast Canc, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USA
关键词
Latent profiles; Health-related quality of life; Breast cancer; PATIENT-REPORTED OUTCOMES; FUNCTIONAL ASSESSMENT; LATENT-CLASS; RACIAL-DIFFERENCES; PHYSICAL-ACTIVITY; THERAPY; POPULATION; SURVIVORS; MODELS; ISSUES;
D O I
10.1007/s11136-017-1533-5
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
We aimed to identify subgroups of women with breast cancer who experience different health-related quality of life (HRQOL) patterns during active treatment and survivorship and determine characteristics associated with subgroup membership. We used data from the third phase of the population-based Carolina Breast Cancer Study and included 2142 women diagnosed with breast cancer from 2008 to 2013. HRQOL was measured, on average, 5 and 25 months post diagnosis. Latent profile analysis was used to identify HRQOL latent profiles (LPs) at each time point. Latent transition analysis was used to determine probabilities of women transitioning profiles from 5 to 25 months. Multinomial logit models estimated adjusted odds ratios (aORs) and 95% confidence intervals for associations between patient characteristics and LP membership at each time point. We identified four HRQOL LPs at 5 and 25 months. LP1 had the poorest HRQOL and LP4 the best. Membership in the poorest profile at 5 months was associated with younger age aOR 0.95; 0.93-0.96, White race aOR 1.48; 1.25-1.65, being unmarried aOR 1.50; 1.28-1.65 and having public aOR 3.09; 1.96-4.83 or no insurance aOR 6.51; 2.12-20.10. At 25 months, Black race aOR 1.75; 1.18-1.82 was associated with the poorest profile membership. Black race and smoking were predictors of deteriorating to a worse profile from 5 to 25 months. Our results suggest patient-level characteristics including age at diagnosis and race may identify women at risk for experiencing poor HRQOL patterns. If women are identified and offered targeted HRQOL support, we may see improvements in long-term HRQOL and better breast cancer outcomes.
引用
收藏
页码:1733 / 1743
页数:11
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