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Yonsei Univ, Coll Dent, Dept Prevent Dent & Publ Oral Hlth, Oral Sci Res Inst,PLUS Project BK21, 50-1 Yonsei Ro, Seoul 03722, South Korea Yonsei Univ, Coll Dent, Dept Prevent Dent & Publ Oral Hlth, Oral Sci Res Inst,PLUS Project BK21, 50-1 Yonsei Ro, Seoul 03722, South Korea