Partial identification of underdetermined compartmental models: A method based on positive linear Lyapunov functions

被引:5
作者
Eisenfeld, J
机构
[1] Department of Mathematics, University of Texas at Arlington, Arlington
关键词
D O I
10.1016/0025-5564(95)00049-6
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
A class of models is considered in which the number of unknown parameters exceeds the number of independent equations that are derived from the input/observation observation configuration. It is shown that, under certain circumstances, if the number of unknown parameters is sufficiently decreased by setting some of the exit parameters to zero, then the fallaciously derived model has the following interesting properties. The functions of time that give the amounts in the compartments are constant multiples of their counterparts in the fallacious model. A subset of the fallacious fractional transfer coefficients have the same values as their counterparts in the true model whereas others yield interval bounds. These and related results are obtained from a method based on positive linear Lyapunov functions.
引用
收藏
页码:111 / 140
页数:30
相关论文
共 21 条
[1]  
ANDERSON DH, 1983, LECT NOTES BIOMATH, V50
[2]  
BELLMAN R, 1970, Mathematical Biosciences, V7, P329, DOI 10.1016/0025-5564(70)90132-X
[3]   ALGORITHMS FOR THE IDENTIFIABLE PARAMETER COMBINATIONS AND PARAMETER BOUNDS OF UNIDENTIFIABLE CATENARY COMPARTMENTAL-MODELS [J].
CHEN, BCM ;
LANDAW, EM ;
DISTEFANO, JJ .
MATHEMATICAL BIOSCIENCES, 1985, 76 (01) :59-68
[4]  
DELFORGE J, 1982, P 10 IMACS WORLD C M, V2, P217
[5]   COMPLETE PARAMETER BOUNDS AND QUASI-IDENTIFIABILITY CONDITIONS FOR A CLASS OF UNIDENTIFIABLE LINEAR-SYSTEMS [J].
DISTEFANO, JJ .
MATHEMATICAL BIOSCIENCES, 1983, 65 (01) :51-68
[6]   POOL SIZE AND MASS FLUX BOUNDS AND QUASIIDENTIFIABILITY RELATIONS FOR CATENARY MODELS [J].
DISTEFANO, JJ ;
CHEN, BC ;
LANDAW, EM .
MATHEMATICAL BIOSCIENCES, 1988, 88 (01) :1-14
[7]   MULTIEXPONENTIAL, MULTICOMPARTMENTAL, AND NONCOMPARTMENTAL MODELING .1. METHODOLOGICAL LIMITATIONS AND PHYSIOLOGICAL INTERPRETATIONS [J].
DISTEFANO, JJ ;
LANDAW, EM .
AMERICAN JOURNAL OF PHYSIOLOGY, 1984, 246 (05) :R651-R664
[8]   STOCHASTIC PARAMETERS IN COMPARTMENTAL SYSTEMS [J].
EISENFELD, J .
MATHEMATICAL BIOSCIENCES, 1980, 52 (3-4) :261-275
[9]   ON WASHOUT IN NON-LINEAR COMPARTMENTAL-SYSTEMS [J].
EISENFELD, J .
MATHEMATICAL BIOSCIENCES, 1982, 58 (02) :259-275
[10]  
EISENFELD J, 1979, MATH BIOSCI, V47, P173