The Influence of Early Life Nutrition on Epigenetic Regulatory Mechanisms of the Immune System

被引：51

作者：

Paparo, Lorella ^{[1
]}

di Costanzo, Margherita ^{[1
]}

di Scala, Carmen ^{[1
]}

Cosenza, Linda ^{[1
]}

Leone, Ludovica ^{[1
]}

Nocerino, Rita ^{[1
]}

Canani, Roberto Berni ^{[1
,2
,3
]}

机构：

[1] Univ Naples Federico II, Dept Translat Med Sci, Pediat Food Allergy Unit, I-80131 Naples, Italy

[2] European Lab Invest Food Induced Dis, I-80131 Naples, Italy

[3] Univ Naples Federico II, CEINGE Adv Biotechnol, I-80131 Naples, Italy

来源：

NUTRIENTS | 2014年 / 6卷 / 11期

关键词：

gut microbiota; short-chain fatty acids; butyrate; food allergy; pregnancy; children; DNA methylation; miRNA; histone deacetylase inhibitors; CHAIN FATTY-ACIDS; ALLERGIC AIRWAY DISEASE; ONE-CARBON METABOLISM; COWS MILK ALLERGY; DNA METHYLATION; GUT MICROBIOTA; INTESTINAL MICROBIOTA; ULCERATIVE-COLITIS; FOLATE-DEPLETION; GENE-EXPRESSION;

D O I：

10.3390/nu6114706

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The immune system is exquisitely sensitive to environmental changes. Diet constitutes one of the major environmental factors that exerts a profound effect on immune system development and function. Epigenetics is the study of mitotically heritable, yet potentially reversible, molecular modifications to DNA and chromatin without alteration to the underlying DNA sequence. Nutriepigenomics is an emerging discipline examining the role of dietary influences on gene expression. There is increasing evidence that the epigenetic mechanisms that regulate gene expression during immune differentiation are directly affected by dietary factors or indirectly through modifications in gut microbiota induced by different dietary habits. Short-chain fatty acids, in particular butyrate, produced by selected bacteria stains within gut microbiota, are crucial players in this network.

引用

收藏

页码：4706 / 4719

页数：14

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