Exploring Network Properties Across Preclinical Stages of Alzheimer's Disease Using a Visual Short-Term Memory and Attention Task with High-Density Electroencephalography: A Brain-Connectome Neurophysiological Study

被引：6

作者：

Lazarou, Ioulietta ^{[1
,2
]}

Georgiadis, Kostas ^{[1
,3
]}

Nikolopoulos, Spiros ^{[1
]}

Oikonomou, Vangelis P. ^{[1
]}

Stavropoulos, Thanos G. ^{[1
]}

Tsolaki, Anthoula ^{[1
,4
]}

Kompatsiaris, Ioannis ^{[1
]}

Tsolaki, Magda ^{[1
,2
,4
]}

机构：

[1] Ctr Res & Technol Hellas CERTH ITI, Informat Technol Inst, Thessaloniki, Greece

[2] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Med, Dept Neurol 1, Macedonia, Greece

[3] Aristotle Univ Thessaloniki, Informat Dept, Macedonia, Greece

[4] Greek Assoc Alzheimers Dis & Related Disorders, Thessaloniki, Greece

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2022年 / 87卷 / 02期

基金：

欧盟地平线“2020”;

关键词：

Alzheimer's disease; brain networks; electroencephalography; mild cognitive impairment; subjective cognitive decline; visual attention; visual short-term memory; MILD COGNITIVE IMPAIRMENT; DEFAULT-MODE NETWORK; LATERAL INTRAPARIETAL AREA; POSTERIOR CINGULATE CORTEX; AGE-RELATED DECLINE; WORKING-MEMORY; TOP-DOWN; FUNCTIONAL CONNECTIVITY; SUSTAINED ATTENTION; MULTIPLE STIMULI;

D O I：

10.3233/JAD-215421

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: Visual short-term memory (VSTMT) and visual attention (VAT) exhibit decline in the Alzheimer's disease (AD) continuum; however, network disruption in preclinical stages is scarcely explored. Objective: To advance our knowledge about brain networks in AD and discover connectivity alterations during VSTMT and VAT. Methods: Twelve participants with AD, 23 with mild cognitive impairment (MCI), 17 with subjective cognitive decline (SCD), and 21 healthy controls (HC) were examined using a neuropsychological battery at baseline and follow-up (three years). At baseline, the subjects were examined using high density electroencephalography while performing a VSTMT and VAT. For exploring network organization, we constructed weighted undirected networks and examined clustering coefficient, strength, and betweenness centrality from occipito-parietal regions. Results: One-way ANOVA and pair-wise t-test comparisons showed statistically significant differences in HC compared to SCD (t (36) = 2.43, p = 0.026), MCI (t (42) = 2.34, p = 0.024), and AD group (t (31) = 3.58, p = 0.001) in Clustering Coefficient. Also with regards to Strength, higher values for HC compared to SCD (t (36) = 2.45, p = 0.019), MCI (t (42) = 2.41, p = 0.020), and AD group (t (31) = 3.58, p = 0.001) were found. Follow-up neuropsychological assessment revealed converge of 65% of the SCD group to MCI. Moreover, SCD who were converted to MCI showed significant lower values in all network metrics compared to the SCD that remained stable. Conclusion: The present findings reveal that SCD exhibits network disorganization during visual encoding and retrieval with intermediate values between MCI and HC.

引用

页码：643 / 664

页数：22