Transplantation of autologous bone marrow-derived mesenchymal stem cells under arthroscopic surgery with microfracture versus microfracture alone for articular cartilage lesions in the knee: A multicenter prospective randomized control clinical trial

被引：69

作者：

Hashimoto, Yusuke ^{[1
]}

Nishida, Yohei ^{[1
]}

Takahashi, Shinji ^{[1
]}

Nakamura, Hiroaki ^{[1
]}

Mera, Hisashi ^{[2
]}

Kashiwa, Kaori ^{[3
]}

Yoshiya, Shinichi ^{[3
]}

Inagaki, Yusuke ^{[4
]}

Uematsu, Kota ^{[4
]}

Tanaka, Yasuhito ^{[4
]}

Asada, Shigeki ^{[5
]}

Akagi, Masao ^{[5
]}

Fukuda, Kanji ^{[6
]}

Hosokawa, Yoshiya ^{[7
]}

Myoui, Akira ^{[7
]}

Kamei, Naosuke ^{[8
]}

Ishikawa, Masakazu ^{[8
]}

Adachi, Nobuo ^{[8
]}

Ochi, Mitsuo ^{[8
]}

Wakitani, Shigeyuki ^{[9
]}

机构：

[1] Osaka City Univ, Dept Orthopaed Surg, Grad Sch Med, Osaka, Japan

[2] Uonuma Kikan Hosp, Dept Orthopaed Surg, Minamiuonuma, Japan

[3] Hyogo Coll Med, Dept Orthopaed Surg, Nishinomiya, Hyogo, Japan

[4] Nara Med Univ, Dept Orthopaed Surg, Nara, Japan

[5] Kindai Univ, Dept Orthopaed Surg, Fac Med, Osaka, Japan

[6] Kindai Univ, Fac Med, Inst Adv Clin Med, Div Cell Biol Regenerat Med, Osaka, Japan

[7] Osaka Univ Hosp, Med Ctr Translat Res, Osaka, Japan

[8] Hiroshima Univ, Dept Orthopaed Surg, Grad Sch Biomed & Hlth Sci, Hiroshima, Japan

[9] Koryokai Hosp, Dept Orthopaed Surg, Osaka, Japan

来源：

REGENERATIVE THERAPY | 2019年 / 11卷

关键词：

Bone marrow-derived mesenchymal stem cells; Microfracture; Prospective randomized control clinical trial; CHONDROCYTE TRANSPLANTATION; INTRAARTICULAR INJECTION; HYALURONIC-ACID; DEFECTS; REPAIR; MOBILIZATION; THERAPY; JOINT;

D O I：

10.1016/j.reth.2019.06.002

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Introduction: To investigate the efficacy of the transplantation of autologous bone marrow-derived mesenchymal stem cells (BMSCs) under arthroscopy with microfracture (MFX) compared with microfracture alone. Methods: Eleven patients with a symptomatic articular cartilage defect of the knee were included in the study. They were randomized to receive BMSCs with MFX (cell-T group, n=7) or MFX alone (control group, n=4). Clinical results were evaluated using International Knee Documentation committee (IKDC) knee evaluation questionnaires and the Knee Injury and Osteoarthritis Outcome Score (KOOS) before and 48 weeks after surgery. Quantitative and qualitative assessments of repair tissue were carried out at 48 weeks by T2 mapping of magnetic resonance images (MRIs) and the magnetic resonance observation of cartilage repair tissue (MOCART) scoring system with follow-up MRI. Results: No significant differences between preoperative and postoperative IKDC and KOOS were observed in the cell-T or control group. However, forty-eight weeks after surgery, the cell-T group showed a trend for a greater KOOS QOL score compared with the control group (79.4 vs. 39.1, respectively; P=0.07). The T2 value did not differ significantly between the two groups, but the mean MOCART score was significantly higher in the cell-T group than in the control group (P=0.02). Conclusions: Compared with MFX alone, BMSC transplantation with MFX resulted in better postoperative healing of the cartilage and subchondral bone as determined by the MOCART score. Clinically, BMSC transplantation with MFX gave a higher KOOS QOL score after 48 weeks. (C) 2019, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

引用

页码：106 / 113

页数：8

共 37 条

[1] Mobilization of bone marrow-derived mesenchymal stem cells into the injured tissues after intraarticular injection and their contribution to tissue regeneration [J].