High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma

被引：53

作者：

Hoda, Mir Alireza ^{[1
,2
]}

Rozsas, Anita ^{[1
,3
]}

Lang, Elisabeth ^{[2
]}

Klikovits, Thomas ^{[1
]}

Lohinai, Zoltan ^{[3
]}

Torok, Szilvia ^{[3
]}

Berta, Judit ^{[3
]}

Bendek, Matyas ^{[3
]}

Berger, Walter ^{[2
]}

Hegedus, Balazs ^{[1
,4
]}

Klepetko, Walter ^{[1
]}

Renyi-Vamos, Ferenc ^{[5
,6
]}

Grusch, Michael ^{[2
]}

Dome, Balazs ^{[1
,3
,5
,6
,7
]}

Laszlo, Viktoria ^{[1
]}

机构：

[1] Med Univ Vienna, Comprehens Canc Ctr Vienna, Translat Thorac Oncol Lab, Div Thorac Surg,Dept Surg, Vienna, Austria

[2] Med Univ Vienna, Comprehens Canc Ctr Vienna, Inst Canc Res, Dept Med 1, Vienna, Austria

[3] Natl Koranyi Inst Pulmonol, Budapest, Hungary

[4] Hungarian Acad Sci, MTA SE Mol Oncol Res Grp, Budapest, Hungary

[5] Natl Inst Oncol, Dept Thorac Surg, Budapest, Hungary

[6] Semmelweis Univ, H-1085 Budapest, Hungary

[7] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Vienna, Austria

来源：

ONCOTARGET | 2016年 / 7卷 / 12期

关键词：

activin A; lung adenocarcinoma; biomarker; metastasis; follistatin; Pathology Section; MALIGNANT PLEURAL MESOTHELIOMA; SQUAMOUS-CELL CARCINOMA; SERUM AMYLOID-A; PROSTATE-CANCER; BREAST-CANCER; ESOPHAGEAL ADENOCARCINOMA; FOLLISTATIN; EXPRESSION; SURVIVAL; PROTEIN;

D O I：

10.18632/oncotarget.7796

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in different tumor types including lung adenocarcinoma (LADC). Here, we report that serum ActA protein levels are significantly elevated in LADC patients (n=64) as compared to controls (n=46, p=0.015). ActA levels also correlated with more advanced disease stage (p<0.0001) and T (p=0.0035) and N (p=0.0002) factors. M1 patients had significantly higher ActA levels than M0 patients (p<0.001). High serum ActA level was associated with poor overall survival (p<0.0001) and was confirmed as an independent prognostic factor (p=0.004). Serum FST levels were increased only in female LADC patients (vs. female controls, p=0.031). Two out of five LADC cell lines secreted biologically active ActA, while FST was produced in all of them. Transcripts of both type I and II ActA receptors were detected in all five LADC cell lines. In conclusion, our study does not only suggest that measuring blood ActA levels in LADC patients might improve the prediction of prognosis, but also indicates that this parameter might be a novel non-invasive biomarker for identifying LADC patients with organ metastases.

引用

页码：13388 / 13399

页数：12

共 58 条

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