An efficient synthesis of 2-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine:: a potent M1 selective muscarinic agonist

被引：16
作者：
Kumar, Y. C. Sunil [1 ]
Sadashiva, M. P. [1 ]
Rangappa, K. S. [1 ]
机构：
[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 26期
关键词：
C-substituted morpholines; 2-acetyl pyridine; arecoline;
D O I：
10.1016/j.tetlet.2007.04.135
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
2-(1-Methyl-1,2,5,6-tetrahydropyridin-3-yl)morpholine is useful for synthesizing potent antimicrobials including the arecoline derivatives, phendimetrazine and polygonapholine and was synthesised in nine steps with an overall yield of 36%. Bromination of 3-acetylpyridine and dehydration of a diol with cyclization were pivotal to the success of the strategy. (c) 2007 Elsevier Ltd. All rights reserved.
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页码：4565 / 4568
页数：4
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