Paediatric anti-NMDA-receptor encephalitis with ovarian teratoma

被引：0

作者：

Kojima, Masato ^{[1
,2
]}

Kurihara, Sho ^{[1
,3
]}

Saeki, Isamu ^{[1
]}

Izumo, Hiroki ^{[4
]}

Tateishi, Yuichi ^{[4
]}

Kobayashi, Yoshiyuki ^{[4
]}

Ishikawa, Nobutsune ^{[4
]}

Arihiro, Koji ^{[5
]}

Takahashi, Shinya ^{[3
]}

Hiyama, Eiso ^{[1
,2
]}

机构：

[1] Hiroshima Univ Hosp, Dept Pediat Surg, Kasumi 1-2-3, Minami, Hiroshima 7348551, Japan

[2] Hiroshima Univ, Nat Sci Ctr Basic Res & Dev N BARD, Kasumi 1-2-3, Minami, Hiroshima 7348551, Japan

[3] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Surg, Kasumi 1-2-3, Minami, Hiroshima 7348551, Japan

[4] Hiroshima Univ Hosp, Dept Pediat, Kasumi 1-2-3, Minami, Hiroshima 7348551, Japan

[5] Hiroshima Univ Hosp, Dept Anat Pathol, Kasumi 1-2-3, Minami, Hiroshima 7348551, Japan

来源：

JOURNAL OF PEDIATRIC SURGERY CASE REPORTS | 2022年 / 83卷

关键词：

Anti-N-Methyl-D-aspartate receptor (NMDAR); encephalitis; Ovarian teratoma; Paediatrics;

D O I：

10.1016/j.epsc.2022.102318

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Herein, we report two paediatric cases of ovarian teratoma-associated anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. We performed surgical resection of the teratomas-enucleation in case 1 and salpingo-oophorectomy in case 2. The pathological diagnoses were immature teratomas with a small number of neuroglial elements, and cerebrospinal fluid (CSF) anti-NMDAR antibody test was positive in both cases. In case 1, the patient showed excellent recovery, and in case 2, neurological symptoms gradually improved. Paediatric cases of ovarian teratomaassociated anti-NMDAR encephalitis are rare, and early surgical resection and immunotherapy are important for good prognosis. We highlight the occurrence of paediatric cases of ovarian teratoma-associated anti-NMDAR encephalitis to create awareness and highlight the importance of surgical resection despite severe neurological symptoms.

引用

页数：5

共 11 条

[1] Ovarian teratoma-associated anti-NMDAR encephalitis: a systematic review of reported cases [J].

Acien, Pedro ;

Acien, Maribel ;

Ruiz-Macia, Eva ;

Martin-Estefania, Carlos .

ORPHANET JOURNAL OF RARE DISEASES, 2014, 9 :157

[2] Malignant tumors in autoimmune encephalitis with anti-NMDA receptor antibodies [J].

Bost, Chloe ;

Chanson, Eve ;

Picard, Geraldine ;

Meyronet, David ;

Mayeur, Marie-Eve ;

Ducray, Francois ;

Rogemond, Veronique ;

Psimaras, Dimitri ;

Antoine, Jean-Christophe ;

Delattre, Jean-Yves ;

Desestret, Virginie ;

Honnorat, Jerome .

JOURNAL OF NEUROLOGY, 2018, 265 (10) :2190-2200

[3] Immunopathological characterization of ovarian teratomas associated with anti-N-methyl-D-aspartate receptor encephalitis [J].

Chefdeville, Aude ;

Treilleux, Isabelle ;

Mayeur, Marie-Eve ;

Couillault, Coline ;

Picard, Geraldine ;

Bost, Chloe ;

Mokhtari, Karima ;

Vasiljevic, Alexandre ;

Meyronet, David ;

Rogemond, Veronique ;

Psimaras, Dimitri ;

Dubois, Bertrand ;

Honnorat, Jerome ;

Desestret, Virginie .

ACTA NEUROPATHOLOGICA COMMUNICATIONS, 2019, 7 (1) :38

[4] Surgical outcomes in patients with anti-N-methyl D-aspartate receptor encephalitis with ovarian teratoma [J].

Dai, Yi ;

Zhang, Junji ;

Ren, Haitao ;

Zhou, Xingnan ;

Chen, Juan ;

Cui, Liying ;

Lang, Jinghe ;

Guan, Hongzhi ;

Sun, Dawei .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2019, 221 (05) :485.e1-485.e10

[5] Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma [J].

Dalmau, Josep ;

Tuzun, Erdem ;

Wu, Hai-yan ;

Masjuan, Jaime ;

Rossi, Jeffrey E. ;

Voloschin, Alfredo ;

Baehring, Joachim M. ;

Shimazaki, Haruo ;

Koide, Rej ;

King, Dale ;

Mason, Warren ;

Sansing, Lauren H. ;

Dichter, Marc A. ;

Rosenfeld, Myrna R. ;

Lynch, David R. .

ANNALS OF NEUROLOGY, 2007, 61 (01) :25-36

[6] An update on anti-NMDA receptor encephalitis for neurologists and psychiatrists: mechanisms and models [J].

Dalmau, Josep ;

Armangue, Thais ;

Planaguma, Jesus ;

Radosevic, Ma ;

Mannara, Francesco ;

Leypoldt, Frank ;

Geis, Christian ;

Lancaster, Eric ;

Titulaer, Maarten J. ;

Rosenfeld, Myrna R. ;

Graus, Francesc .

LANCET NEUROLOGY, 2019, 18 (11) :1045-1057

[7] Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis in Children and Adolescents [J].

Florance, Nicole R. ;

Davis, Rebecca L. ;

Lam, Christopher ;

Szperka, Christina ;

Zhou, Lei ;

Ahmad, Saba ;

Campen, Cynthia J. ;

Moss, Heather ;

Peter, Nadja ;

Gleichman, Amy J. ;

Glaser, Carol A. ;

Lynch, David R. ;

Rosenfeld, Myrna R. ;

Dalmau, Josep .

ANNALS OF NEUROLOGY, 2009, 66 (01) :11-18

[8] Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: a retrospective study [J].

Gresa-Arribas, Nuria ;

Titulaer, Maarten J. ;

Torrents, Abiguei ;

Aguilar, Esther ;

McCracken, Lindsey ;

Leypoldt, Frank ;

Gleichman, Amy J. ;

Alice-Gordon, Rita ;

Rosenfeld, Myrna R. ;

Lynch, David ;

Graus, Francesc ;

Dalmau, Josep .

LANCET NEUROLOGY, 2014, 13 (02) :167-177

[9] Histopathological characterization of the neuroglial tissue in ovarian teratoma associated with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis [J].

Iemura, Yoshiki ;

Yamada, Yosuke ;

Hirata, Masahiro ;

Kataoka, Tatsuki R. ;

Minamiguchi, Sachiko ;

Haga, Hinonori .

PATHOLOGY INTERNATIONAL, 2018, 68 (12) :677-684

[10] Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study [J].

Titulaer, Maarten J. ;

McCracken, Lindsey ;

Gabilondo, Inigo ;

Armangue, Thais ;

Glaser, Carol ;

Iizuka, Takahiro ;

Honig, Lawrence S. ;

Benseler, Susanne M. ;

Kawachi, Izumi ;

Martinez-Hernandez, Eugenia ;

Aguilar, Esther ;

Gresa-Arribas, Nuria ;

Ryan-Florance, Nicole ;

Torrents, Abiguei ;

Saiz, Albert ;

Rosenfeld, Myrna R. ;

Balice-Gordon, Rita ;

Graus, Francesc ;

Dalmau, Josep .

LANCET NEUROLOGY, 2013, 12 (02) :157-165

← 1 2 →