Diversity on demand: multi-ancestry meta-analysis improves genetic risk prediction in prostate cancer

被引：0

作者：

Leon, Andres F. ^{[1
]}

Chau, Cindy H. ^{[1
]}

Price, Douglas K. ^{[1
]}

Figg, William D. ^{[1
]}

机构：

[1] NCI, Mol Pharmacol Sect, Genitourinary Malignancies Branch, Ctr Canc Res,NIH, 9000 Rockville Pike,Bldg 10 Room 5A03, Bethesda, MD 20892 USA

来源：

AMERICAN JOURNAL OF CLINICAL AND EXPERIMENTAL UROLOGY | 2021年 / 9卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Prostate cancer; genome-wide association study; multi-ancestry; health disparities; SUSCEPTIBILITY LOCI;

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Several genome-wide association studies have been conducted to identify genetic risk factors associated with prostate cancer, but their ability to discover new genetic variants and their applicability across ancestry groups have been limited by their lack of genetic diversity, owing to an underrepresentation of non-European populations. A recent meta-analysis published in Nature Genetics by Conti et al. has used a multi-ancestry approach to identify 86 new genetic loci associated with prostate cancer risk, refine leads in known risk regions, and develop a genetic risk score that is transferable across population groups. The findings of this study represent a significant advancement in genetic risk prediction for prostate cancer and their incorporation into standard screening protocols may lead to significant improvements in clinical outcomes.

引用

页码：189 / 193

页数：5

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