miR-188 suppresses tumor progression by targeting SOX4 in pediatric osteosarcoma

被引：13

作者：

Pan, Lu ^{[1
]}

Meng, Lingxin ^{[2
]}

Liang, Feng ^{[1
]}

Cao, Li ^{[3
]}

机构：

[1] Peoples Hosp Rizhao, Dept Pediat Surg, 126 Taian Rd, Rizhao 276800, Shandong, Peoples R China

[2] Peoples Hosp Rizhao, Dept Oncol, Rizhao 276800, Shandong, Peoples R China

[3] Peoples Hosp Rizhao, Dept Anaesthesia Operat, Rizhao 276800, Shandong, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2018年 / 18卷 / 01期

关键词：

microRNA-188; SOX4; progression; pediatric osteosarcoma; SQUAMOUS-CELL CARCINOMA; INHIBITS PROLIFERATION; UP-REGULATION; INVASION; CANCER; MICRORNAS; MIGRATION; GROWTH; METASTASIS; EXPRESSION;

D O I：

10.3892/mmr.2018.8997

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

microRNA-188 (miR-188) acts as a tumor suppressor in various types of human cancer, including glioma, oral squamous cell carcinoma and hepatocellular carcinoma. However, the function and mechanism of miR-188 in pediatric osteosarcoma (OS) have yet to be investigated. In the present study reverse transcription-quantitative polymerase chain reaction revealed that miR-188 expression was significantly downregulated in pediatric OS tissues and cell lines. miR-188 overexpression markedly suppressed OS cell proliferation, migration and invasion, and induced cellular apoptosis. in vivo assay demonstrated that miR-188 overexpression inhibited tumor growth. miR-188 targeted SOX4 to regulate its expression. miR-188 expression was inversely correlated with SOX4 in pediatric OS tissues. SOX4 restoration abrogated the inhibitory effects of miR-188 on OS cells. The results of the present study indicated that miR-188 suppressed pediatric OS progression by targeting SOX4.

引用

页码：441 / 446

页数：6

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