Impact of RSV Coinfection on Human Bocavirus in Children with Acute Respiratory Infections

被引：28

作者：

Sun, Huiming ^{[1
]}

Sun, Jiyang ^{[1
]}

Ji, Wei ^{[1
]}

Hao, Chuangli ^{[1
]}

Yan, Yongdong ^{[1
]}

Chen, Zhengrong ^{[1
]}

Wang, Yuqing ^{[1
]}

机构：

[1] Soochow Univ, Dept Resp Med, Childrens Hosp, 303 Jing De Rd, Suzhou, Jiangsu, Peoples R China

来源：

JOURNAL OF TROPICAL PEDIATRICS | 2019年 / 65卷 / 04期

基金：

中国国家自然科学基金;

关键词：

coinfection; human bocavirus; respiratory syncytial virus; disease severity; acute respiratory infections; TRACT INFECTIONS; DISEASE SEVERITY; BRONCHIOLITIS; ASSOCIATION; LOAD;

D O I：

10.1093/tropej/fmy057

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objective: The objective of this study was to assess epidemiological and clinical features of human bocavirus (HBoV) coinfection with other viruses. Method: Children coinfected with HBoV between January 2012 and December 2014 were enrolled and retrospectively reviewed. Result: A total of 984 patients were stratified into five groups: HBoV infection alone (n = 249), respiratory syncytial virus (RSV) infection alone (n = 649), HBoV coinfection with RSV (n = 28), with human rhinovirus (HRV) (n = 39) and with other virus (n = 19). Length of hospitalization was longer in HBoV coinfection with RSV group than HBoV (9.0 days vs. 7.0 days, p = 0.001), RSV (9.0 days vs. 8.0 days, p = 0.016) infection alone group. Pneumonia was more common in the HBoV coinfection with RSV group compared with the HBoV, RSV infection alone group, respectively (75.0% vs. 44.2%, 31.3%, p<0.001). HBoV DNA copy numbers (383 000 copies/ml) were positively correlated with the length of hospitalization (r = 0.334, p<0.001). Conclusion: HBoV coinfection with RSV increases HBoV infection severity.

引用

页码：342 / 351

页数：10

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