Osteoporosis in rheumatoid arthritis

被引：30

作者：

Suzuki, Y ^{[1
]}

Mizushima, Y ^{[1
]}

机构：

[1] St Marianna Univ, Sch Med, Inst Med Sci, Miyamae Ku, Kawasaki, Kanagawa 216, Japan

来源：

OSTEOPOROSIS INTERNATIONAL | 1997年 / 7卷

关键词：

LOW-DOSE CORTICOSTEROIDS; BONE-MINERAL DENSITY; POSTMENOPAUSAL WOMEN; JOINT DESTRUCTION; DISEASE-ACTIVITY; INTERLEUKIN-1; CELLS; GLUCOCORTICOIDS; PROSTAGLANDINS; METHOTREXATE;

D O I：

10.1007/BF03194376

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Periarticular osteopenia of appendicular bones occurs early in the course of RA.Loss of the balance between bone resorption and formation contributes to the development of perarticular osteopenia and might be mediated through increased production of cytokines and prostaglandins by the synovium and bone marrow. Generalized osteopenia isalso common and leads to an increased risk of fracture. Although the pathogenesis of this osteopenia is considered to be multifactorial, disease activity, immobility, corticosteroids and menopausal status are the important determinants.

引用

页码：217 / 222

页数：6

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