No Oxygen? No Glucose? No Problem: Fatty Acid Catabolism Enhances Effector CD8+ TILs

被引：14

作者：

Bailis, Will ^{[1
]}

Shyer, Justin A. ^{[1
]}

Chiorazzi, Michael ^{[1
]}

Flavell, Richard A. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Dept Immunobiol, 333 Cedar St, New Haven, CT 06520 USA

来源：

CANCER CELL | 2017年 / 32卷 / 03期

关键词：

D O I：

10.1016/j.ccell.2017.08.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The tumor microenvironment presents metabolic constraints to immunosurveiling cells. In this issue of Cancer Cell, Zhang et al. demonstrate that CD8(+) TILs reprogram under hypoxic and hypoglycemic conditions, regaining effector function by engaging fatty acid catabolism, which is promoted by fenofibrate and synergistic with immune checkpoint blockade therapy.

引用

页码：280 / 281

页数：3