Eco-friendly C-3 Selenation of Imidazo[1,2-a]pyridines in Ionic Liquid

被引：14

作者：

Wang, Xin ^{[1
]}

Mu, Shiqiang ^{[1
]}

Sun, Ting ^{[1
]}

Sun, Kai ^{[1
]}

机构：

[1] Anyang Normal Univ, Coll Chem & Chem Engn, Anyang 455000, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 39卷 / 10期

基金：

中国国家自然科学基金;

关键词：

selenation; imidazo[1,2-a]pyridines; C-3; functionalization; electrophilic mechanism; DIRECT ARYLATION; SELENIUM POWDER; IMIDAZOHETEROCYCLES; SULFENYLATION; EFFICIENT; CATALYST; ORGANOSELENIUM; CHALCOGENATION; THIOCYANATION; BROMIDES;

D O I：

10.6023/cjoc201904057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An relative eco-friendly protocol for the direct C-3 selenation of imidazo[1,2-a]pyridines with vorious organoselenides has been developed, gaving the desired products in moderate to excellent yields. Preliminary experimental results are consistent with a C-3 electrophilic functionalization mechanism. The features with relative green reaction conditions, broad substrate scope, and easy scale-up operation would make this strategy promising and important for the preparation of nitrogen and selenium containing molecules.

引用

页码：2802 / 2807

页数：6

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