High (1 GHz) repetition rate compact femtosecond laser:: A powerful multiphoton tool for nanomedicine and nanobiotechnology

被引：20
作者：
Ehlers, A.
Riemann, I.
Martin, S.
Le Harzic, R.
Bartels, A.
Janke, C.
Koenig, K.
机构：
[1] Fraunhofer Inst Biomed Technol IBMT, D-66386 St Ingbert, Germany
[2] JenLab GmbH, D-07745 Jena, Germany
[3] Gigaopt GmbH, D-78462 Constance, Germany
[4] Univ Saarland, Fac Mechatron, D-66041 Saarbrucken, Germany
来源：
JOURNAL OF APPLIED PHYSICS | 2007年 / 102卷 / 01期
关键词：
D O I：
10.1063/1.2745367
中图分类号：
O59 [应用物理学];
学科分类号：
摘要：
Multiphoton tomography of human skin and nanosurgery of human chromosomes have been performed with a 1 GHz repetition rate laser by the use of the commercially available femtosecond multiphoton laser tomograph DermaInspect as well as a compact galvoscanning microscope. We performed the autofluorescence tomography up to 100 mu m in the depth of human skin. Submicron cutting lines and hole drillings have been conducted on labeled human chromosomes.
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页数：6
相关论文
共 20 条
[1]  
BABU A, 1995, HUMAN CHROMOSOMES PR
[2]   Femtosecond Ti:sapphire ring laser with a 2-GHz repetition rate and its application in time-resolved spectroscopy [J].
Bartels, A ;
Dekorsy, T ;
Kurz, H .
OPTICS LETTERS, 1999, 24 (14) :996-998
[3]  
BARTELS A, 2001, C LASERS ELECTROOPTI, P27
[4]   Real-time second-harmonic-generation microscopy based on a 2-GHz repetition rate Ti:sapphire laser [J].
Chu, SW ;
Liu, TM ;
Sun, CK .
OPTICS EXPRESS, 2003, 11 (08) :933-938
[5]   Skin imaged by femtosecond laser irradition: a risk assessment for in vivo applications [J].
Fischer, F. ;
Volkmer, B. ;
Puschmann, S. ;
Greinert, R. ;
Breitbart, W. ;
Kiefer, J. ;
Wepf, R. .
BIOPHOTONICS AND NEW THERAPY FRONTIERS, 2006, 6191
[6]   Two-photon fluorescence microscopy of in-vivo human skin [J].
Hendriks, RFM ;
Lucassen, GW .
LASER MICROSCOPY, 2000, 4164 :116-121
[7]   In vivo assessment of human skin aging by multiphoton laser scanning tomography [J].
Koehler, Martin Johannes ;
Koenig, Karsten ;
Elsner, Peter ;
Bueckle, Rainer ;
Kaatz, Martin .
OPTICS LETTERS, 2006, 31 (19) :2879-2881
[8]   In vivo drug screening in human skin using femtosecond laser multiphoton tomography [J].
Koenig, K. ;
Ehlers, A. ;
Stracke, F. ;
Riemann, I. .
SKIN PHARMACOLOGY AND PHYSIOLOGY, 2006, 19 (02) :78-88
[9]   Nanodissection of human chromosomes with near-infrared femtosecond laser pulses [J].
König, K ;
Riemann, I ;
Fritzsche, W .
OPTICS LETTERS, 2001, 26 (11) :819-821
[10]  
König K, 1999, CELL MOL BIOL, V45, P195
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