Turnover of memory-phenotype CD8+ T cells

被引：35
|
作者：
Sprent, J [1 ]
机构：
[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 03期
关键词：
memory CD8(+) cells; IL-15; interferons; T-cell turnover; IN-VIVO; DEATH; PROLIFERATION; HOMEOSTASIS; ACTIVATION; GENERATION; INDUCTION; INFECTION; EXPANSION; IMMUNITY;
D O I：
10.1016/S1286-4579(03)00015-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Memory-phenotype (CD44(hi)) T cells are presumed to represent the long-lived progeny of T cells responding to various environmental antigens. For CD8(+) T cells, the background rate of proliferation (turnover) of memory-phenotype cells is increased following exposure to infectious agents. This increase in turnover is controlled by interferons (IFN-I and IFN-gamma) and is mediated by IL-15. Unlike IFNs, IL-15 is directly stimulatory for CD44(hi) CD8(+) cells. In addition to controlling proliferation of these cells, IL-15 may also play a vital role in keeping CD44(hi) CD8(+) cells alive. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：227 / 231
页数：5
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