Vibrational spectroscopy of a non-aromatic amino acid-based model peptide:: identification of the γ-turn motif of the peptide backbone

被引:46
作者
Compagnon, I
Oomens, J
Bakker, J
Meijer, G
von Helden, G
机构
[1] EURATOM, FOM, Inst Plasma Phys Rijnhuizen, NL-3439 MN Nieuwegein, Netherlands
[2] Max Planck Gesell, Fritz Haber Inst, D-14195 Berlin, Germany
关键词
D O I
10.1039/b417204c
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The first infrared hole burning spectrum of a gas-phase neutral peptide not containing an aromatic amino acid is presented. In the model peptide Z-Pro-NHMe, the amide I and II bands in the 1500 - 1800 cm(-1) region appear to be a clear diagnostic for the secondary structure of the backbone, while the analysis of a series of coupled CH bending modes in the 1000 - 1500 cm(-1) region allows to distinguish between different possible orientations of the chromophore. The geometry of the peptide is strongly constrained by the proline and only one conformation of the backbone is observed, which is identified as a hydrogen bonded gamma-turn.
引用
收藏
页码:13 / 15
页数:3
相关论文
共 23 条
[21]   Sugars in the gas phase:: the spectroscopy and structure of jet-cooled phenyl β-D-glucopyranoside [J].
Talbot, FO ;
Simons, JP .
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2002, 4 (15) :3562-3565
[22]   Vibrational spectroscopic detection of beta- and gamma-turns in synthetic and natural peptides and proteins [J].
Vass, E ;
Hollósi, M ;
Besson, F ;
Buchet, R .
CHEMICAL REVIEWS, 2003, 103 (05) :1917-1954
[23]   The spectroscopy of solvation in hydrogen-bonded aromatic clusters [J].
Zwier, TS .
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, 1996, 47 :205-241