Changes in Gastric Inhibitory Polypeptide (GIP) After Roux-en-Y Gastric Bypass in Obese Patients: a Meta-analysis

被引：8

作者：

Gao, Zhiguang ^{[1
]}

Yang, Jingge ^{[2
]}

Liang, Yuzhi ^{[3
]}

Yang, Sen ^{[4
]}

Zhang, Tao ^{[1
]}

Gong, Zuyuan ^{[1
]}

Li, Min ^{[1
]}

机构：

[1] Southern Med Univ, Dept Gastrointestinal Surg, Affiliated Dongguan Shilong Peoples Hosp, Dongguan 523320, Peoples R China

[2] Jinan Univ, Affiliated Hosp 1, Dept Gastrointestinal Surg, Guangzhou, Peoples R China

[3] Southern Med Univ, Affiliated Dongguan Shilong Peoples Hosp, Dept Med Imaging, Dongguan 523320, Peoples R China

[4] Guangdong Med Univ, Zhanjiang, Guangdong, Peoples R China

来源：

OBESITY SURGERY | 2022年 / 32卷 / 08期

关键词：

Roux-en-Y gastric bypass; Gastric inhibitory polypeptide; GIP; Meta-analysis; INSULIN SENSITIVITY; GASTROINTESTINAL HORMONES; GLUCOSE-HOMEOSTASIS; SLEEVE GASTRECTOMY; DIABETES-MELLITUS; METABOLIC SURGERY; SINGLE-CENTER; BODY-WEIGHT; OPEN-LABEL; FOLLOW-UP;

D O I：

10.1007/s11695-022-05959-4

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

This meta-analysis aimed to evaluate changes in GIP after RYGB in obese patients. We searched PubMed, EMBASE, and CENTRAL for relevant studies from database inception through July 2021. Articles were eligible for inclusion if they reported pre-operative and post-operative fasting GIP levels. We found fasting GIP levels had a decreasing tendency. The decrease in fasting glucose and postprandial GIP levels was also observed. Subgroup analysis indicated diabetic subjects tended to have a more obvious fasting GIP reduction compared to non-diabetic individuals. Meta-regression showed that the amount of weight loss (% total body weight), gastric pouch volume, alimentary limb length, and biliopancreatic limb length were not related to fasting GIP decrease. Fasting GIP levels decreased significantly after RYGB in obese people, especially in diabetic patients.

引用

页码：2706 / 2716

页数：11

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