Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group

被引：44
作者：
Sun, Ranfeng [1 ]
Li, Yongqiang [1 ]
Lue, Maoyun [1 ]
Xiong, Lixia [1 ]
Wang, Qingmin [1 ]
机构：
[1] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Benzoylphenylureas (BPUs); Oxime ether; Oxime ester; Structure-activity relationship; Larvicidal activity; Insect growth regulator; INSECTICIDAL ACTIVITY; MOIETY; BIOISOSTERISM; SUBSTITUENTS; INHIBITORS; REDUCTION; ALDOXIMES; EFFICIENT;
D O I：
10.1016/j.bmcl.2010.04.144
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of new structural benzoylphenylureas (BPUs) containing oxime ether and oxime ester group were designed and synthesized. The larvicidal activities against Oriental armyworm and mosquito of these benzoylphenylureas were evaluated and the result of bioassay displayed specific structure-activity relationship (SAR). Most of the compounds exhibited excellent larvicidal activities against Oriental armyworm and mosquito. Interestingly, some compounds showed different structure-activity relationship towards diamondback moth, beet armyworm, and corn borer although three tested insects all belong to the same insect order. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4693 / 4699
页数：7
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