Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

被引：22

作者：

Alexandru, Maria-Gabriela ^{[1
]}

Velickovic, Tanja Cirkovic ^{[2
]}

Jitaru, Ioana ^{[1
]}

Grguric-Sipka, Sanja ^{[3
]}

Draghici, Constantin ^{[4
]}

机构：

[1] Univ Politehn Bucuresti, Dept Inorgan Chem, Bucharest 011061, Romania

[2] Univ Belgrade, Fac Chem, Dept Biochem, Belgrade 11000, Serbia

[3] Univ Belgrade, Dept Inorgan Chem, Fac Chem, Belgrade 11000, Serbia

[4] Romanian Acad, CD Nenitescu Ctr Organ Chem, Bucharest 71141, Romania

来源：

CENTRAL EUROPEAN JOURNAL OF CHEMISTRY | 2010年 / 8卷 / 03期

关键词：

Aminothiazole; Cytotoxicity; HeLa; PBMC; 2,4-DISUBSTITUTED THIAZOLES; INHIBITORS; RUTHENIUM(III); ANTIBACTERIAL; DISCOVERY; SCAFFOLD; LIGANDS; AGENTS; HELA;

D O I：

10.2478/s11532-010-0022-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper presents the synthesis of complex compounds of type [M(L1)(2)], where M(II) = Cu (1), Co (2), Zn (3), L1 = 2-aminothiazole-4-acetate and [Mn(L1)(2)(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)(2)(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control.

引用

页码：639 / 645

页数：7

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