Exploiting vita-PAMPs in vaccines

被引：24
作者：
Blander, J. Magarian [1 ,2 ,3 ,4 ,5 ]
Barbet, Gaetan [1 ,2 ]
机构：
[1] Cornell Univ, Jill Roberts Inst Res Inflammatory Bowel Dis, Weill Cornell Med, New York, NY 10021 USA
[2] Cornell Univ, Weill Cornell Med, Joan & Sanford I Weill Dept Med, Gastroenterol & Hepatol Div, New York, NY 10021 USA
[3] Cornell Univ, Weill Cornell Med, Dept Microbiol & Immunol, New York, NY 10021 USA
[4] Cornell Univ, Weill Cornell Med, Sandra & Edward Meyer Canc Ctr, New York, NY 10021 USA
[5] Cornell Univ, Weill Cornell Med, Weill Cornell Grad Sch Med Sci, Immunol & Microbial Pathogenesis Program, New York, NY 10021 USA
来源：
CURRENT OPINION IN PHARMACOLOGY | 2018年 / 41卷
基金：
美国国家卫生研究院;
关键词：
FOLLICULAR HELPER-CELL; NLRP3; INFLAMMASOME; BACTERIAL RNA; T-CELLS; MICROBIAL VIABILITY; ANTIBODY-PRODUCTION; INFLUENZA-VIRUS; HUMAN TLR8; DIFFERENTIATION; RECOGNITION;
D O I：
10.1016/j.coph.2018.05.012
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Live attenuated vaccines elicit stronger protective immunity than dead vaccines. Distinct PAMPs designated as vita-PAMPs signify microbial viability to innate immune cells. Two vita-PAMPs have been characterized: cyclic-di-adenosine-monophosphate (c-di-AMP) and prokaryotic messenger RNA (mRNA). c-di-AMP produced by live Gram-positive bacteria elicits augmented production of STING-dependent type-I interferon, whereas prokaryotic mRNA from live bacteria is detected by TLR8 enabling discrimination of live from dead bacteria. Bacterial mRNA from live Gram-negative bacteria triggers a heightened type-I interferon and NLRP3 inflammasome response. By mobilizing unique viability associated innate responses, vita-PAMPs mobilize adaptive immunity that best elicits protection, including follicular T helper cell and antibody responses. Here, we review the molecular mechanisms that confer the unique adjuvanticity of vita-PAMPs and discuss their applications in vaccine design.
引用
收藏
页码：128 / 136
页数：9
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