Characterization of a genetic element carrying the macrolide efflux gene mef(A) in Streptococcus pneumoniae

被引：100
作者：
Santagati, M
Iannelli, F
Oggioni, MR
Stefani, S
Pozzi, G
机构：
[1] Univ Siena, Dipartimento Biol Mol, Sez Microbiol, I-53100 Siena, Italy
[2] Univ Catania, Dipartimento Sci Microbiol, Catania, Italy
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 09期
关键词：
D O I：
10.1128/AAC.44.9.2585-2587.2000
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The mef(A) gene from a clinical isolate of Streptococcus pneumoniae exhibiting the M-type resistance to macrolides was found to be part of the 7,244-bp chromosomal element Tn1207.1, which contained 8 open reading frames. orf2 encodes a resolvase/invertase, and orf5 is a homolog of the macrolide-streptogramin B resistance gene msr(SA).
引用
收藏
页码：2585 / 2587
页数：3
相关论文
共 41 条
[1]   SEQUENCE OF A STAPHYLOCOCCAL PLASMID GENE, VGA, ENCODING A PUTATIVE ATP-BINDING PROTEIN INVOLVED IN RESISTANCE TO VIRGINIAMYCIN A-LIKE ANTIBIOTICS [J].
ALLIGNET, J ;
LONCLE, V ;
ELSOLH, N .
GENE, 1992, 117 (01) :45-51
[2]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[3]   Incidence of mefA and mefE genes in viridans group streptococci [J].
Arpin, C ;
Canron, MH ;
Maugein, J ;
Quentin, C .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (09) :2335-2336
[4]   Presence of mefA and mefE genes in Streptococcus agalactiae [J].
Arpin, C ;
Daube, H ;
Tessier, F ;
Quentin, C .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (04) :944-946
[5]   Emergence of mefA and mefE genes in beta-haemolytic streptococci and pneumococci in France [J].
Arpin, C ;
Canron, MH ;
Noury, P ;
Quentin, C .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1999, 44 (01) :133-134
[6]   MOLECULAR-GENETICS OF THE CHLORAMPHENICOL-RESISTANCE TRANSPOSON TN4451 FROM CLOSTRIDIUM-PERFRINGENS - THE TNPX SITE-SPECIFIC RECOMBINASE EXCISES A CIRCULAR TRANSPOSON MOLECULE [J].
BANNAM, TL ;
CRELLIN, PK ;
ROOD, JI .
MOLECULAR MICROBIOLOGY, 1995, 16 (03) :535-551
[7]   Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships [J].
Brenner, SE ;
Chothia, C ;
Hubbard, TJP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6073-6078
[8]   Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes [J].
Clancy, J ;
Petitpas, J ;
DibHajj, F ;
Yuan, W ;
Cronan, M ;
Kamath, AV ;
Bergeron, J ;
Retsema, JA .
MOLECULAR MICROBIOLOGY, 1996, 22 (05) :867-879
[9]   The resolvase/invertase domain of the site-specific recombinase TnpX is functional and recognizes a target sequence that resembles the junction of the circular form of the Clostridium perfringens transposon Tn4451 [J].
Crellin, PK ;
Rood, JI .
JOURNAL OF BACTERIOLOGY, 1997, 179 (16) :5148-5156
[10]   Phenotypes and genotypes of erythromycin-resistant Streptococcus pyogenes strains in Italy and heterogeneity of inducibly resistant strains [J].
Giovanetti, E ;
Montanari, MP ;
Mingoia, M ;
Varaldo, PE .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (08) :1935-1940
12345