Mechanisms and pathways of innate immune activation and regulation in health and cancer

被引：264

作者：

Cui, Jun ^{[1
]}

Chen, Yongjun ^{[1
]}

Wang, Helen Y. ^{[2
]}

Wang, Rong-Fu ^{[2
]}

机构：

[1] Sun Yat Sen Univ, Key Lab Gene Engn, Minist Educ, State Key Lab Biocontrol,Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

[2] Houston Methodist Res Inst, Ctr Inflammat & Epigenet, Houston, TX USA

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2014年 / 10卷 / 11期

基金：

中国国家自然科学基金;

关键词：

cancer; inflammation; innate immunity; PRRs; type I interferon; pathogen recognition receptors; PAMPs; pathogen-associated molecular patterns; DAMPs; danger-associated molecular patterns; TLRs; Toll-like receptors; RLRs; RIG-I-like receptors; NLRs; Nod- like receptors; ALRs; AIM2-like receptors; CLRs; C-type lectin receptors; IFN; interferon; DCs; dendritic cells; NOD; nucleotide-binding oligomerization domain; LRR; leucine-rich repeat; RIG-I; retinoic acid-inducible gene 1; LGP; 2; laboratory of genetics and physiology 2; MDA5; melanoma differentiation-associated protein 5; AIM2; absent in melanoma 2; IFI16; gamma-inducible protein 16; DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; cGAS; cyclic GMP-AMP synthase; TIR; Toll IL-1 receptor; LPS; lipopolysaccharide; MyD88; myeloid differentiation factor 88; TIRAP; TIR domain-containing adapter protein; TRIF; TIR domain-containing adaptor inducing IFN-b; TRAM; TRIF-related adaptor molecule; SARM; sterile a- and armadillo motif-containing protein; IRAK; interleukin-1 receptor-associated kinase; TRAF; TNFR-associated factor; NEMO; NF-kB essential modulator; IKK; IkB kinase; TAK1; TGF-b-activating kinase 1; IRF; interferon regulatory factor; RIP; receptor-interacting protein; TANK; TRAF family-member-associated NF-kB activator; TBK1; TANK binding kinase 1; IKKi; inducible IkB kinase; iE-DAP; g-D-glutamyl-meso-diaminopimelic acid; MDP; muramyl dipeptide; Atg16L; autophagy related 16-like; MAVS; mitochondrial antiviral signaling protein; ASC; apoptosis-associated speck-like protein containing a CARD; CARD; caspase recruitment domain; LT; lethal toxin; NAIPs; neuronal apoptosis inhibitory proteins; STING; stimulator of interferon gene; CMV; cytomegalovirus; ER; endoplasmic reticulum; CDNs; cyclic dinucleotides; CYLD; the familial cylindromatosis tumor suppressor gene; Nrdp1; neuregulin receptor degradation protein 1; TRIMs; tripartite motif containing proteins; LBP; LPS-binding protein; SIGIRR; single Ig IL-1-related receptor; TRAILR; tumor-necrosis factor-related apoptosis-inducing ligand receptor; cIAP; cellular inhibitor of apoptosis protein; ROS; reactive oxygen species; BMM; bone marrow-derived macrophage; SOCS; suppressor of cytokine signaling; GBP5; guanylate-binding protein 5; PKC-d; protein kinase C delta; PKR; dsRNA-dependent protein kinase; ULK1; autophagy related serine threonine UNC-51-like kinase; AMPK; AMP activated protein kinase; LUBAC; linear ubiquitin assembly complex; GSK3; Glycogen synthase kinase 3; MIB; mind bomb; TRIP; TRAF-interacting protein; cDC; conventional dendritic cell; pDC; plasmacytoid dendritic cell; KSHV; Kaposi's sarcoma-associated herpesvirus; RAUL; RTA-associated E3 ligase; RACK1; receptor for activated C kinase 1; HCC; hepatocellular carcinoma; NF-KAPPA-B; TOLL-LIKE RECEPTORS; NOD-LIKE RECEPTOR; PATTERN-RECOGNITION RECEPTORS; UBIQUITIN-DEPENDENT KINASE; TUMOR-SUPPRESSOR CYLD; CYTOSOLIC DNA SENSOR; SINGLE-STRANDED RNA; IFN-BETA PRODUCTION; T-CELL DEVELOPMENT;

D O I：

10.4161/21645515.2014.979640

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Research on innate immune signaling and regulation has recently focused on pathogen recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense diverse microbial invasions or danger signals, and initiate innate immune signaling pathways, leading to proinflammatory cytokines production, which, in turn, instructs adaptive immune response development. Despite the diverse functions employed by innate immune signaling to respond to a variety of different pathogens, the innate immune response must be tightly regulated. Otherwise, aberrant, uncontrolled immune responses will lead to harmful, or even fatal, consequences. Therefore, it is essential to better discern innate immune signaling and many regulators, controlling various signaling pathways, have been identified. In this review, we focus on the recent advances in our understanding of the activation and regulation of innate immune signaling in the host response to pathogens and cancer.

引用

页码：3270 / 3285

页数：16

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