Preparation of biodegradable gelatin/PVA porous scaffolds for skin regeneration

被引：68

作者：

Mahnama, Hossein ^{[1
]}

Dadbin, Susan ^{[2
]}

Frounchi, Masoud ^{[1
]}

Rajabi, Sareh ^{[3
]}

机构：

[1] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran

[2] Radiat Applicat Res Sch, Nucl Sci & Technol Res Inst, Tehran, Iran

[3] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, Tehran, Iran

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期

关键词：

Freeze gelation-drying; gelatin; porous scaffold; PVA; skin cell; NANOFIBROUS SCAFFOLD; CROSS-LINKING; TISSUE; FABRICATION; PVA; ALCOHOL; SPONGE;

D O I：

10.1080/21691401.2016.1193025

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Porous scaffolds composed of gelatin/poly (vinyl alcohol), (Gel/PVA), were prepared using combination of freeze gelation and freeze drying methods. The effect of polymer concentration, gelatin/PVA ratio, and glutaraldehyde/gelatin ratio (GA/Gel) was investigated on morphology of pores, swelling ratio, biodegradation, and skin cell culture. At optimum preparation conditions the scaffolds had uniform pore size distributions showing high swelling ratio of 23.6. The scaffolds were of biodegradable nature and almost degraded in 28 days. Human dermal fibroblast cells (HDF) were cultured on the scaffolds and MTS assay was conducted to evaluate the influence of PVA on growth and proliferation of the cells.

引用

页码：928 / 935

页数：8

共 50 条

[21] Preparation and properties of silk fibroin/gelatin porous scaffolds for liver tissue engineering
Hao, Xing
He, Jiankang
Gao, Kun
Li, Dichen
Liu, Yaxiong
Hsi-An Chiao Tung Ta Hsueh/Journal of Xi'an Jiaotong University, 2011, 45 (11): : 121 - 126
[22] Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method
Wu, X.
Liu, Y.
Li, X.
Wen, P.
Zhang, Y.
Long, Y.
Wang, X.
Guo, Y.
Xing, F.
Gao, J.
ACTA BIOMATERIALIA, 2010, 6 (03) : 1167 - 1177
[23] Preparation and characterization of porous scaffolds from chitosan-collagen-gelatin composite
Tylingo, Robert
Gorczyca, Grzegorz
Mania, Szymon
Szweda, Piotr
Milewski, Slawomir
REACTIVE & FUNCTIONAL POLYMERS, 2016, 103 : 131 - 140
[24] A review of preparation methods of porous skin tissue engineering scaffolds
Zhang, Zefei
Feng, Yihua
Wang, Li
Liu, Dongxue
Qin, Changcai
Shi, Yanbin
MATERIALS TODAY COMMUNICATIONS, 2022, 32
[25] Preparation and in vitro characterization of electrospun PVA scaffolds coated with bioactive glass for bone regeneration
Gao, Chunxia
Gao, Qiang
Li, Yadong
Rahaman, Mohamed N.
Teramoto, Akira
Abe, Koji
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2012, 100A (05) : 1324 - 1334
[26] Biodegradable PCL/fibroin/hydroxyapatite porous scaffolds prepared by supercritical foaming for bone regeneration
Diaz-Gomez, Luis
Garcia-Gonzalez, Carlos A.
Wang, Jiamian
Yang, Fang
Aznar-Cervantes, Salvador
Luis Cenis, Jose
Reyes, Ricardo
Delgado, Araceli
Evora, Carmen
Concheiro, Angel
Alvarez-Lorenzo, Carmen
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 527 (1-2) : 115 - 125
[27] Crosslinking strategies for porous gelatin scaffolds
Van Vlierberghe, Sandra
JOURNAL OF MATERIALS SCIENCE, 2016, 51 (09) : 4349 - 4357
[28] Preparation of the honeycomb patterned porous film of biodegradable polymer for tissue engineering scaffolds
Sato, K
Hasebe, K
Tanaka, M
Takebayashi, M
Nishikawa, K
Shimomura, M
Kawai, T
Matsushita, M
Todo, S
ASIANANO 2002, PROCEEDINGS, 2003, : 315 - 319
[29] Preparation and properties of porous Zn-based scaffolds as biodegradable implants: a review
Zhao, Lichen
Yuan, Pengkai
Zhang, Mengsi
Wang, Xin
Qi, Yumin
Wang, Tiebao
Cao, Bin
Cui, Chunxiang
JOURNAL OF MATERIALS SCIENCE, 2023, 58 (20) : 8275 - 8316
[30] Crosslinking strategies for porous gelatin scaffolds
Sandra Van Vlierberghe
Journal of Materials Science, 2016, 51 : 4349 - 4357

← 1 2 3 4 5 →