Preparation of biodegradable gelatin/PVA porous scaffolds for skin regeneration

被引：68
|
作者：
Mahnama, Hossein [1 ]
Dadbin, Susan [2 ]
Frounchi, Masoud [1 ]
Rajabi, Sareh [3 ]
机构：
[1] Sharif Univ Technol, Dept Chem & Petr Engn, Tehran, Iran
[2] Radiat Applicat Res Sch, Nucl Sci & Technol Res Inst, Tehran, Iran
[3] ACECR, Royan Inst Stem Cell Biol & Technol, Cell Sci Res Ctr, Dept Stem Cells & Dev Biol, Tehran, Iran
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 05期
关键词：
Freeze gelation-drying; gelatin; porous scaffold; PVA; skin cell; NANOFIBROUS SCAFFOLD; CROSS-LINKING; TISSUE; FABRICATION; PVA; ALCOHOL; SPONGE;
D O I：
10.1080/21691401.2016.1193025
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Porous scaffolds composed of gelatin/poly (vinyl alcohol), (Gel/PVA), were prepared using combination of freeze gelation and freeze drying methods. The effect of polymer concentration, gelatin/PVA ratio, and glutaraldehyde/gelatin ratio (GA/Gel) was investigated on morphology of pores, swelling ratio, biodegradation, and skin cell culture. At optimum preparation conditions the scaffolds had uniform pore size distributions showing high swelling ratio of 23.6. The scaffolds were of biodegradable nature and almost degraded in 28 days. Human dermal fibroblast cells (HDF) were cultured on the scaffolds and MTS assay was conducted to evaluate the influence of PVA on growth and proliferation of the cells.
引用
收藏
页码：928 / 935
页数：8
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