Renin-Angiotensin-Aldosterone System Inhibition Overview of the Therapeutic Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, Mineralocorticoid Receptor Antagonists, and Direct Renin Inhibitors

被引：27

作者：

Mercier, Kelly ^{[1
]}

Smith, Holly ^{[2
]}

Biederman, Jason ^{[2
,3
]}

机构：

[1] Botsford Hosp, Farmington Hills, MI 48336 USA

[2] Garden City Hosp, Garden City, MI 48135 USA

[3] Hypertens Nephrol Associates, PC, Livonia, MI 48152 USA

来源：

PRIMARY CARE | 2014年 / 41卷 / 04期

关键词：

Renin; Angiotensin; Aldosterone; Review; Combination; Diabetes; Kidney disease; Albuminuria; BLOOD-PRESSURE CONTROL; CHRONIC HEART-FAILURE; VENTRICULAR SYSTOLIC FUNCTION; ACUTE MYOCARDIAL-INFARCTION; DIABETIC-NEPHROPATHY; RENAL OUTCOMES; ANTIHYPERTENSIVE AGENTS; DOSE COMBINATION; RANDOMIZED-TRIAL; DOUBLE-BLIND;

D O I：

10.1016/j.pop.2014.08.002

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) therapy in hypertensive diabetic patients with macroalbuminuria, microalbuminuria, or normoalbuminuria has been repeatedly shown to improve cardiovascular mortality and reduce the decline in glomerular filtration rate. Renin-angiotensin-aldosterone system (RAAS) blockade in normotensive diabetic patients with normoalbuminuria or microalbuminuria cannot be advocated at present. Dual RAAS inhibition with ACE inhibitors plus ARBs or ACE inhibitors plus direct renin inhibitors has failed to improve cardiovascular or renal outcomes but has predisposed patients to serious adverse events.

引用

页码：765 / +

页数：15

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