Methamphetamine-induced apoptosis is attenuated in the striata of copper-zinc superoxide dismutase transgenic mice

被引：71

作者：

Deng, XL ^{[1
]}

Cadet, JL ^{[1
]}

机构：

[1] NIDA, Mol Neuropsychiat Sect, Intramurla Res Program, Baltimore, MD 21224 USA

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 83卷 / 1-2期

关键词：

methamphetamine; apoptosis; TUNEL; caspase;

D O I：

10.1016/S0169-328X(00)00169-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Administration of methamphetamine caused significant increases in terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL)-positive cells, in poly (ADP-ribose) polymerase (PARP) cleavage, as well as in caspase-3 activity in the striata of C57BL/6J mice. In contrast, all these effects were markedly suppressed in the copper-zinc superoxide dismutase transgenic mice. These results indicate that superoxide radicals might be important factors in METH-induced cell death. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：121 / 124

页数：4

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