Liposomes and virosomes as delivery systems for antigens, nucleic acids and drugs

被引：218
作者：
Felnerova, D [1 ]
Viret, JF [1 ]
Glück, R [1 ]
Moser, C [1 ]
机构：
[1] Berna Biotech Ltd, CH-3018 Bern, Switzerland
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 2004年 / 15卷 / 06期
关键词：
D O I：
10.1016/j.copbio.2004.10.005
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid-based vesicles are a very promising approach to treat diseases such as cancer, chronic infections and auto-immunity. Modern drug encapsulation methods allow efficient packing of therapeutic substances inside liposomes, thereby reducing the systemic toxicity of the drugs. Specific targeting can enhance the therapeutic effect of the drugs through their accumulation at the diseased site. In the vaccine field, the integration of functional viral envelope proteins into liposomes has led to an antigen carrier and delivery system termed a virosome, a clinically proven vaccine platform for subunit vaccines with an excellent immunogenicity and tolerability profile.
引用
收藏
页码：518 / 529
页数：12
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