White matter integrity and cognitive performance in children with prenatal methamphetamine exposure

被引:29
作者
Roos, Annerine [1 ]
Kwiatkowski, Maja A. [2 ]
Fouche, Jean-Paul [3 ]
Narr, Katherine L. [4 ]
Thomas, Kevin G. F. [2 ]
Stein, Dan J. [5 ]
Donald, Kirsty A. [6 ]
机构
[1] Dept Psychiat, SU UCT MRC Unit Anxiety & Stress Disorders, ZA-7505 Tygerberg, South Africa
[2] Univ Cape Town, Dept Psychol, ZA-7700 Rondebosch, South Africa
[3] Univ Stellenbosch, Dept Psychiat, ZA-7600 Stellenbosch, South Africa
[4] Univ Calif Los Angeles, Dept Neurol, Los Angeles, CA 90024 USA
[5] Univ Cape Town, Dept Psychiat & Mental Hlth, ZA-7700 Rondebosch, South Africa
[6] Univ Cape Town, Div Dev Paediat, ZA-7700 Rondebosch, South Africa
基金
英国医学研究理事会; 新加坡国家研究基金会; 芬兰科学院;
关键词
Prenatal; Methamphetamine; Diffusion tensor imaging; Cognitive function; Development; BRAIN CHANGES; DIFFUSION; ALCOHOL; DAMAGE; DYSMYELINATION; DEMYELINATION; DEFICITS; ATLAS;
D O I
10.1016/j.bbr.2014.11.005
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
There is emerging evidence on the harmful effects of prenatal methamphetamine (MA) exposure on the structure and function of the developing brain. However, few studies have assessed white matter structural integrity in the presence of prenatal MA exposure, and results are inconsistent. This investigation thus used diffusion tensor imaging (DTI) to investigate white matter microstructure and cognitive performance in a group of prenatal MA exposed (or MA) children and controls of similar age. Seventeen MA children and 15 healthy controls (aged 6-7 years) underwent DTI and assessment of motor function and general cognitive ability. Whole brain analyses of white matter structure were performed using FSL's tract-based spatial statistics comparing fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD) and axial diffusivity (AD). Mean diffusion values were extracted from white matter regions shown to differ across groups to determine whether variations in FA predicted cognitive performance. Analyses were controlled for maternal nicotine use. MA children showed significantly lower FA as well as higher MD, RD and AD in tracts that traverse striatal, limbic and frontal regions. Abnormal FA levels in MA children were significantly associated with poorer motor coordination and general cognitive ability sub-items that relate to aspects of executive function. Our findings suggest that, consistent with previous studies in older children, there are disruptions of white matter microstructural integrity in striatal, limbic and frontal regions of young MA exposed children, with prominent cognitive implications. Future longitudinal studies may clarify how prenatal MA exposure affects white matter structural connectivity at different stages of brain maturation. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码:62 / 67
页数:6
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